背景:通常在眼周区域可以看到最明显的面部衰老迹象。然而,由于眼周解剖位置的特殊性,眼周恢复仍然具有挑战性。
目的:我们旨在评估部分消融CO2激光促进重组人胶原渗透在眼周恢复中的有效性和安全性。
方法:这项为期3个月的前瞻性单盲和自我对照试验纳入了26例眼周衰老患者,他们接受了部分消融CO2激光和激光促进重组人胶原渗透治疗。在治疗之后,在治疗前后通过各种眼周皮肤老化指数对患者进行定量评估,并监测相关不良事件.
结果:治疗后3个月,患者眼周皮肤老化指数显着改善,详细介绍了下眼睑皮肤韵律下降了47.3%,下眼睑皮肤纹理减少41.4%,静态乌鸦的脚减少了35.0%,上眼睑松弛量减少29.3%,与基线相比,MRD1增加20.2%(p<0.05)。此外,上下眼睑超声下的总皮肤厚度增加(5.6%和3.3%,p分别<0.05)。此外,6名患者(23.1%,6/26)出现红斑2周,2例(2/26,7.7%)出现轻度色素沉着,持续3个月。
结论:分次烧蚀CO2激光联合激光促进重组人胶原渗透是一种安全有效的眼周年轻化治疗方法。
BACKGROUND: The most visible sign of facial aging is often seen in the periocular area. However, periocular rejuvenation remains challenging due to the particularity of periocular anatomic locations.
OBJECTIVE: We aimed to evaluate the efficacy and safety of the fractional-ablative CO2 laser-facilitated recombinant human collagen
permeation in periocular rejuvenation.
METHODS: This 3-month prospective single-blinded and self-controlled trial enrolled 26 patients with periocular aging who underwent the treatments of fractional-ablative CO2 laser along with laser-facilitated recombinant human collagen
permeation. Following the treatments, the patients were quantitatively assessed by various periocular skin aging indices before and after the treatment and monitored for any related adverse events.
RESULTS: The patients showed significant improvements with the periocular skin aging indices 3 months after the treatments, which were detailed with a 47.3% decrease in lower eyelid skin rhytids, a 41.4% decrease in the lower eyelid skin texture, a 35.0% decrease in the static crow\'s feet, a 29.3% decrease in the amount of upper eyelid laxity, and a 20.2% increase in the MRD1 as compared with baseline (p < 0.05). Moreover, total skin thickness under ultrasound was increased in both upper and lower eyelids (5.6% and 3.3%, p < 0.05, respectively). Moreover, six patients (23.1%, 6/26) had erythema for 2 weeks, and two (2/26, 7.7%) had mild hyperpigmentation for 3 months.
CONCLUSIONS: Fractional-ablative CO2 laser combined with laser-facilitated recombinant human collagen
permeation can be a safe and effective treatment for periocular rejuvenation.