OBJECTIVE: In this study, our aim was to develop and validate the effectiveness of diverse radiomic models for distinguishing between gnathic fibrous dysplasia (FD) and ossifying fibroma (OF) before surgery.
METHODS: We enrolled 220 patients with confirmed FD or OF. We extracted radiomic features from nonenhanced CT images. Following dimensionality reduction and feature selection, we constructed radiomic models using logistic regression, support vector machine, random forest, light gradient boosting machine, and eXtreme gradient boosting. We then identified the best radiomic model using receiver operating characteristic (ROC) curve analysis. After combining radiomics features with clinical features, we developed a comprehensive model. ROC curve and decision curve analysis (DCA) demonstrated the models\' robustness and clinical value.
RESULTS: We extracted 1834 radiomic features from CT images, reduced them to eight valuable features, and achieved high predictive efficiency, with area under curves (AUC) exceeding 0.95 for all the models. Ultimately, our combined model, which integrates radiomic and clinical data, displayed superior discriminatory ability (AUC: training cohort 0.970; test cohort 0.967). DCA highlighted its optimal clinical efficacy.
CONCLUSIONS: Our combined model effectively differentiates between FD and OF, offering a noninvasive and efficient approach to clinical decision-making.

UNASSIGNED: Preoperative imaging for some unusual lesions in the sellar region can pose challenges in establishing a definitive diagnosis, impacting treatment strategies.
UNASSIGNED: This study is a retrospective analysis of eight cases involving unusual sellar region lesions, all treated with endoscopic endonasal transsphenoidal surgery (EETS). We present the clinical, endocrine, and radiological characteristics, along with the outcomes of these cases.
UNASSIGNED: Among the eight cases, the lesions were identified as follows: Solitary fibrous tumor (SFT) in one case, Lymphocytic hypophysitis (LYH) in one case, Cavernous sinus hemangiomas (CSH) in one case, Ossifying fibroma (OF) in two cases; Sphenoid sinus mucocele (SSM) in one case, Pituitary abscess (PA) in two cases. All patients underwent successful EETS, and their diagnoses were confirmed through pathological examination. Postoperatively, all patients had uneventful recoveries without occurrences of diabetes insipidus or visual impairment.
UNASSIGNED: Our study retrospectively analyzed eight unusual lesions of the sellar region. Some lesions exhibit specific imaging characteristics and clinical details that can aid in preoperative diagnosis and inform treatment strategies for these unusual sellar diseases.

Rhabdomyosarcoma (RMS) with TFCP2 rearrangement has been identified recently. This entity has a distinctive clinicopathologic features: a rapidly aggressive clinical course, a preference for the craniofacial bones, a spindle and epithelioid histomorphology, and positive immunohistochemistry for epithelial markers, ALK, and myogenic markers. RMS with TFCP2 rearrangement is rare and may be misdiagnosed as other spindle cell tumors. Here, we report a case of this entity arising in the mandible, which was initially diagnosed as ossifying fibroma in primary tumor in another hospital. A 26-year-old man presented with a recurred mass in the mandible for 1 month after the operation of mandibular tumor. The first excisional specimen was initially diagnosed as ossifying fibroma in another hospital. Histopathologic examination revealed the tumor with a hybrid spindle cell and epithelioid cytomorphology, spindle cells and spindle-to-epithelioid cells with eosinophilic and rich cytoplasm, with high-grade features, prominent nucleoli and some atypical mitosis. Immunohistochemical analysis revealed positivity for desmin, MYOD1, pan-keratin, ALK (5A4), ALK (D5F3). Based on the morphology and immunophenotype, molecular studies were performed, which revealed a FUS::TFCP2 fusion transcript, confirming the diagnosis of Rhabdomyosarcoma with FUS::TFCP2 fusion. Making a correct diagnosis is primarily dependent on awareness by the pathologist of this rare subtype of RMS and careful histopathological evaluation, supported by immunohistochemical and molecular analysis, to avoid potential diagnostic pitfalls.

BACKGROUND: Ossifying fibroma of the paranasal sinuses and skull base in paediatric patients is difficult to operate and can recur easily after surgery. This study aimed to analyse factors associated with recurrence after transnasal endoscopic resection of ossifying fibroma in paediatric patients.
METHODS: This retrospective observational study included 34 patients under 17 years of age who underwent transnasal endoscopic resection of ossifying fibroma of the paranasal sinuses and skull base from 2005 to 2021 at a single tertiary medical centre. Clinical indicators such as age; surgical history; pathological type; intraoperative bleeding; and orbit, anterior skull base, sphenoid bone, sella turcica, clivus, or frontal sinus involvement were subjected to univariate analysis using the χ2 test, to investigate whether any of these factors affected recurrence.
RESULTS: All 34 patients underwent transnasal endoscopic resection. The follow-up period was 6-120 months (mean: 48.0 months). Five patients experienced local recurrence during the follow-up period (14.7%). Results of χ2 tests indicated that a history of previous surgery, the amount of intraoperative bleeding, and sphenoid and/or sella turcica and clivus involvement were significantly associated with recurrence (P < 0.05). Age; pathological stage; and orbit, anterior skull base, and frontal sinus involvement were not associated with recurrence (P > 0.05).
CONCLUSIONS: The increased risk of recurrence after transnasal endoscopic resection of nasal-skull base ossifying fibroma should be considered during endoscopic surgery in paediatric patients with a history of previous surgery, intraoperative bleeding tendency, and sphenoid and/or sella turcica and clivus involvement. These patients require careful postoperative follow-up.

UNASSIGNED: Osteoblastoma is quite rare in the oromaxillo-facial region, while the mandible is always the predilection. However, in our case, the lesion was located in the left temporal articular tubercle, involving the adjacent skull base, which is extremely rare in the literature.
UNASSIGNED: It had been diagnosed as the most common temporomandibular joint disorder in the local hospital before the patient came to our department, mainly due to the primary symptom, that was, the patient got pain in the left temporomandibular joint area while opening the mouth. However, we found a mass of bone lesions at the left temporal articular tubercle in MRI and cone beam CT, and it turned out to be an osteoblastoma after surgery. The patient\'s primary symptom disappeared after recovering from the surgery, and there have been no indications of complication or recurrence up to now.
UNASSIGNED: Osteoblastoma is very rare in the temporomandibular joint region. It could easily miss the possibility of a benign tumor due to its unusual location and confusing chief complaint in this case. Our report provides experience in the identification of osteoblastoma in rare sites.

OBJECTIVE: A variety of approaches for resection of the ossifying fibromas in sinonasal cavities have been described. However, for those involving the anterior skull base, endoscopic surgery remains challenging because of limitations in identification of tumor boundaries from the anterior skull base and proper control of the tumor-feeding vessel. This study aimed to describe a technique for resection of ossifying fibromas involving the anterior skull base through an endoscopic endonasal trans-agger nasi approach, based on anatomic studies and surgeries.
METHODS: Two human cadaveric heads were prepared for study of the anatomic relationship between agger nasi and anterior skull base. Two clinical cases were used to illustrate the technique and feasibility of the approach.
RESULTS: The agger nasi was located anterior and inferior to the frontal ostium and the anterior skull base. The frontal ostium and anterior skull base could be visualized and accessed under the 0-degree endoscope by removing the agger nasi. Application of the endoscopic endonasal trans-agger nasi approach in the two patients resulted in complete resection of the tumors with no surgical complications.
CONCLUSIONS: An endoscopic endonasal trans-agger nasi approach provides a direct access to the anterior skull base. It would be feasible, effective, and safe for selected cases of ossifying fibroma involving anterior skull base.

Objective:To analyze the clinical features and discuss the treatment of ossifying fibroma in the nasal cavity and sinuses. Method:The patients were performed surgical treatment after admission. 6 cases were treated by endoscopic transnasal approach with image guidance system to resect the mass, 8 cases were operated by simple endoscopic approach, tumor resection was performed via endoscopic surgery with external approach in 2 cases, and endoscopic surgery combined with modified Caldwell-Luc procedure in 1 case. 1 patient was operated through labiolingual groove approach. Result:The intraoperative blood loss of ossified fibroma patients was large, with an average blood loss of 550ml. All the patients were followed up for 6 months to 8 years, 15 patients with complete resection had no recurrence after surgery, and 3 patients with partial resection survived with tumor. Conclusion:Ossifying fibroma in the nasal cavity and sinuses can be completely resected by nasal endoscopic surgery with less trauma and good effect. Transnasal endoscopic surgery assisted by image navigation system can protect important structures in lesions involving orbital cardboard and anterior skull base. Nasal endoscopic surgery combined with small eyebrow incision approach is feasible for ossifying fibroma invading frontal sinus. Ossifying fibroma, which requires adequate preoperative evaluation and blood preparation is prone to bleeding, and lesions with rich blood supply need preoperative interventional therapy.
目的：探讨鼻窦骨化纤维瘤的治疗方法并分析其临床特点。 方法：18例鼻窦骨化纤维瘤患者均行手术治疗，其中6例利用电磁导航辅助鼻内镜下切除肿瘤，8例行单纯鼻内镜下肿瘤切除，2例行鼻内镜下鼻外联合径路肿瘤切除，1例行鼻内镜下下鼻道开窗入路肿瘤切除术，1例唇龈沟入路肿瘤切除。 结果：骨化纤维瘤患者术中出血量较大，平均出血量550 mL。所有患者术后随访6个月～8年，15例完全切除者术后均未复发，3例部分切除者带瘤生存。 结论：鼻窦骨化纤维瘤经鼻内镜手术可彻底切除病变，创伤小且疗效好。对侵犯眶纸板和前颅底的病变，采用电磁导航辅助技术可保护重要结构；对侵犯额窦的病变可行鼻内镜联合眉弓小切口进路。骨化纤维瘤易出血，需术前充分评估并备血，血运丰富的瘤体需术前辅以介入治疗。.

Ossifying fibroma (OF) is a benign tumor commonly occurring in the mandible and maxilla. Spinal involvement of OFs is of great rarity. To the best of our knowledge, only 3 cases in the thoracic and lumbar spine have been reported.
We present the case of a 22-year-old woman with an OF of the atlas, which, to the best of our knowledge, is the first described OF in the cervical spine. The related data were also reviewed. Only 3 spinal OFs involving the thoracic spine to the sacrum have been reported.
Spinal involvement of OFs seldom occurs. To the best of our knowledge, we have reported the first OF involving the cervical spine. Differentiating OFs from primary spinal tumors is necessary. OFs have locally aggressive behavior and a high risk of recurrence. Complete resection, followed by regular examinations, should be the ideal choice for treatment.

To compare the clinical characteristics of osteoma, ossifying fibroma (OF) and fibrous dysplasia (FD) in the paranasal sinus and craniofacial regions.
Totally 282 patients (112 males, 170 females) with osteoma (161), OF (44), and FD (77) involving the paranasal sinus, skull base and orbit treated surgically from January 2012 to August 2018 were analyzed retrospectively.
For osteoma, OF and FD, the onset ages were 40.3 (6-75), 24.5 (5-62), and 15 (1-63) years, and the most common locations were ethmoid sinus (49.7%), maxilla (36.4%) and maxilla (49.4%), respectively. There were significant differences of the preoperative serum alkaline phosphatase (ALP) levels between patients with osteoma (65 [25,184] U/L), OF (85.5 [41,474] U/L), and FD (104 [39,362] U/L) (Z = 44.9, P < .05). The ALP levels of OF and FD patients were comparable between monostotic and polyostotic lesions (P > .05). The recurrent rates of osteoma, OF, and FD were 0%, 13.6%, and 15.6%, respectively. The recurrent OF cases had significantly higher ALP level than the primary ones (283.5 [108,474] U/L vs. 76 [41,348] U/L, U = 14, P < .05).
There are differences in the onset age, location, and recurrence rate among osteoma, OF and FD involving the paranasal sinus and craniofacial region. Osteoma most commonly occurs in the ethmoid sinus, while OF and FD involve the maxilla most and are more likely to involve the orbit and the skull base, respectively. Endoscopic surgery is currently the main method for treatment, but individualized treatment regimen should be developed for patients.
IV Laryngoscope, 131:E1-E7, 2021.

Objective:To compare and analyze the incidence, clinical features ,imaging features, the preoperative serum alkalinosis phosphatase (ALP) and recurrence rates of osteoma, ossifying fibroma (OF), and fibrous dysplasia (FD) in sinus and maxillofacial benign fibrosis (FOLS). Method: The 273 cases of FOLS with paranasal sinus and maxillofacial region in our hospital, among which there were 153 cases of osteoma, 44 cases of OF, and 76 cases of FD, were reviewed retrospectively and were follow-up for 6 months to 5 years. The incidence, gender, age, lesion location, preoperative serum ALP levels and recurrence rate of different lesions were analyzed and compared. Result:Most Osteoma occurred in paranasal sinus (72.5%),among which the most common part was ethmoid sinus (50.3%) and followed by the frontal sinus (22.1%),the ratio of female to male was 2:1,and there were 27 cases (17.7%) accompanied by sinusitis.None of the patients relapsed. Most OF occurred in the maxillofaCIal bone (65.9%) and most of the lesions were monostotic (75.0%).For those occurred in the paranasal sinuses,the ethmoid sinus (27.3%)were the most common part than others. The ratio of femal to male was almost 1∶1 and there were 12 cases (27.3%) accompanied by sinusitis. The recurrence rate of the OF was 13.6%.Most FD occured in maxillofacial bone (64.5%) were the monostotic form(64.5%) ,and in which the most common part was the maxilla (50.0%). While,most of those occurred in the paranasal sinuses were the polyostotic ones,and sphenoid sinus (34.2%) were the most common parts.The ratio of femal to male was almost 1∶1 and there were 10 cases (13.2%) accompanied by sinusitis. 12 cases relapsed (14.5%),and there were 9 cases (75.0%) acceptted the first surgery before the age of 20.The average age of onset among Osteoma［(40.7±14.55)y］,OF［(28.0±17.9)y］ and FD［(20.32±15.2)y］ were significant different (P<0.01).The preoperative serum ALP content among Osteoma［(68.3±24.1)U/L, OF(130.1±107.0) U/L and FD were (127.7±78.7) U/L significant different(P<0.01).Nevertheless,there were no differences of the preoperative serum ALP content between the monostotic and polyostotic in OF cases［(117.2±92.6) U/L,(168.7±140.1) U/L respectively,( P>0.01)］,as well as that between FD cases［(122.2±82.9) U/L, (137.7±70.7) U/L (P>0.01)］. Conclusion:The differences of the inCIdence,the age of onset,leision location,preoperative serum ALP content and reccurence rate among Osteoma,OF and FD are statistically significant.Surgery is the most effective treatment at present.