目的:本研究的目的是评估甲状旁腺功能亢进症(PHPT)之间的关联,甲状旁腺激素水平,和钙水平的患者诊断为良性纤维骨病变,如纤维发育不良(FD),骨化性纤维瘤(OF),中央巨细胞肉芽肿(GCG)。
方法:这是一个回顾性研究,单中心研究来自接受FD手术治疗的患者样本,OF,和GCG在1996年至2021年间在梅奥诊所工作。患者人口统计学,PHPT的历史,组织病理学诊断,和相关的实验室值,如甲状旁腺激素(PTH),血清钙,维生素D,收集碱性磷酸酶。
结果:在诊断为FD的患者中(n=64),OF(n=24),和GCG(n=5),2例患者(3.1%)被诊断为PHPT,1名患者(4.2%),0名患者(0%),分别。3例(4.7%)FD患者PTH水平升高(>65pg/mL),1名患者(4.2%)患有OF,1例(20%)GCG患者。FD组的平均(标准偏差)钙水平为9.3(0.6)mg/dL,OF组9.4(0.5)mg/dL,和9.3(0.6)mg/dL的GCG组。包括FD在内的纤维骨性颌骨肿瘤患者,OF,与普通人群相比,GCG可能增加PHPT的风险。
结论:良性颌骨肿瘤包括FD患者,OF,与普通人群相比,GCG可能增加PHPT的风险。治疗这些良性肿瘤的外科医生需要认识到这些发现,获得适当的实验室研究,并纳入多学科护理,包括内分泌学家,内分泌外科医生,还有颌面外科医生.
OBJECTIVE: The purpose of this study is to evaluate the association between hyperparathyroidism (PHPT), parathyroid hormone levels, and calcium levels in patients diagnosed with benign fibro-osseous lesions such as fibrous dysplasia (FD), ossifying fibroma (OF), central giant cell granulomas (GCG).
METHODS: This is a retrospective, single-center study from a sample of patients who underwent surgical treatment of FD, OF, and GCG at Mayo Clinic between 1996 and 2021. Patient demographics, history of PHPT, histopathological diagnosis, and relevant laboratory values such as parathyroid hormone (PTH), serum calcium, vitamin D, and alkaline phosphatase were collected.
RESULTS: Of the patients diagnosed with FD (n = 64), OF (n = 24), and GCG (n = 5), a diagnosis of PHPT was found in 2 patients (3.1%), 1 patient (4.2%), and 0 patients (0%), respectively. Elevated PTH levels (>65 pg/mL) were observed in 3 patients (4.7%) with FD, 1 patient (4.2%) with OF, and 1 patient (20%) with GCG. Mean (standard deviation) calcium levels were 9.3 (0.6) mg/dL in the FD group, 9.4 (0.5) mg/dL in the OF group, and 9.3 (0.6) mg/dL in the GCG group. Patients with fibro-osseous jaw tumors including FD, OF, and GCG may have increased risk of PHPT compared to the general population.
CONCLUSIONS: Patients with benign jaw tumors including FD, OF, and GCG may have increased risk of PHPT compared to the general population. Surgeons treating these benign tumors need to be cognizant of these findings, obtain appropriate laboratory studies, and incorporate multidisciplinary care including endocrinologists, endocrine surgeons, and maxillofacial surgeons.