背景:工作场所中的个人暴露于各种环境中,任务,和时间表。先前的研究表明,职业暴露与慢性肾脏疾病(CKD)风险增加之间存在联系。然而,工作环境的社会条件也可能是CKD的重要影响因素。此外,个体可能同时遇到多种职业相关危险因素,强调调查不同工作条件对CKD的联合风险的重要性。
方法:对65,069名年龄在40至69岁无CKD的基线(2006-2010)的UKBiobank参与者进行了前瞻性分析。制定了一份自我管理的问卷,评估了工作条件和工作条件风险评分。回答“有时”或“经常”暴露于职业热量或职业二手烟烟雾的参与者;参与轮班工作或繁重的工作量(“通常”或“总是”),被归类为高风险工作条件。如果分组为高风险,每个工作条件得分为1,如果不是,则为0。工作条件风险评分等于这四个工作条件的总和。Cox比例风险回归模型用于估计工作条件与CKD发病率之间的关联。
结果:平均随访时间为6.7年。在调整人口统计后,生活方式,和工作时间因素,针对重工作负载开发CKD的危险比,轮班工作,职业二手烟暴露,职业热暴露为1.24(95CI=1.03,1.51),1.33(95CI=1.10,1.62),1.13(95CI=1.01,1.26),1.11(95CI=0.99,1.24),分别。发现CKD的风险与工作条件风险评分的增加显着相关。与工作条件风险评分为0的人相比,工作条件风险评分为4的人患CKD的风险高88.0%(95%CI=1.05,3.35)。
结论:不良工作条件,特别是当结合考虑时,可以显着提高慢性肾脏病(CKD)的风险。这些结果为实施预防CKD的措施提供了参考。
BACKGROUND: Individuals in the workplace are exposed to various environments, tasks, and schedules. Previous studies have indicated a link between
occupational exposures and an increased risk of chronic kidney disease (CKD). However, the social conditions of the work environment may also be a crucial contributing factor to CKD. Furthermore, individuals may encounter multiple
occupational-related risk factors simultaneously, underscoring the importance of investigating the joint risk of different working conditions on CKD.
METHODS: A prospective analysis of 65,069 UK Biobank participants aged 40 to 69 years without CKD at baseline (2006-2010) was performed. A self-administered questionnaire assessed working conditions and a working conditions risk score were developed. Participants who answered \"sometimes\" or \"often\" exposure to
occupational heat or
occupational secondhand cigarette smoke; involved in shift work or heavy workloads (\"usually\" or \"always\"), were grouped as high-risk working conditions. Each working condition was scored as 1 if grouped as high-risk, and 0 if not. The working conditions risk score was equal to the sum of these four working conditions. Cox proportional hazard regression models were used to estimate the associations between working conditions and CKD incidence.
RESULTS: The mean follow-up time was 6.7 years. After adjusting for demographic, lifestyle, and working time factors, the hazard ratios for the development of CKD for heavy workloads, shift work,
occupational secondhand cigarette smoke exposure, and
occupational heat exposure were 1.24 (95%CI = 1.03, 1.51), 1.33 (95%CI = 1.10, 1.62), 1.13 (95%CI = 1.01, 1.26), 1.11 (95%CI = 0.99, 1.24), respectively. The risk of CKD was found to be significantly associated with an increasing working conditions risk score. Individuals with a working conditions risk score of 4 had an 88.0% (95% CI = 1.05, 3.35) higher risk of developing CKD when compared to those with a working conditions risk score of 0.
CONCLUSIONS: Adverse working conditions, particularly when considered in combination, can significantly elevate the risk of chronic kidney disease (CKD). These results provide a reference for implementing measures to prevent CKD.