UVA1光疗,一种新的治疗方法,最近在治疗掌plant脓疱病(PPP)中显示出良好的疗效。目的比较UVA1和窄带UVB(NB-UVB)治疗PPP的疗效。根据左右随机表,PPP患者被随机分配到UVA1或NB-UVB治疗。这两种治疗每周进行三次,最多30次。临床评估基于掌plant脓疱性银屑病面积和严重程度指数(PPPASI)评分。共有64名患者完成了研究。UVA1和NB-UVB治疗均显示治疗期结束时PPPASI评分与基线值相比有统计学显著降低(P<0.05)。在30个疗程时,与NB-UVB治疗的患者相比,UVA1治疗组的PPPASI评分平均降低幅度明显更大(6.0±2.4vs.4.4±1.4,P<0.05)。两组均未观察到光毒性反应或大疱性变化。NB-UVB和UVA1光疗对PPP均有显著改善。UVA1光疗治疗PPP疗效优于NB-UVB照射。
UVA1 phototherapy, a new therapeutic approach, has recently been shown good efficacy in the treatment of palmoplantar pustulosis (PPP). The purpose of this study was to compare the efficacy of UVA1 and narrowband UVB (NB-UVB) therapy in the treatment of PPP. Patients with PPP were randomly assigned to either UVA1 or NB-UVB therapy according to a left-right randomization table. Both treatments were performed three times weekly for up to 30 sessions. Clinical evaluation was based on the Palmoplantar Pustular Psoriasis Area and Severity Index (PPPASI) score. Totally 64 patients completed the study. Both UVA1 and NB-UVB therapy showed a statistically significant reduction of PPPASI score compared with the baseline value at the end of the treatment period (P < 0.05). There was a significantly greater mean reduction of PPPASI score in the UVA1 treated group when compared to the NB-UVB treated patients at 30 sessions (6.0 ± 2.4 vs. 4.4 ± 1.4, P < 0.05). No phototoxic reaction or bullous changes were observed in either group. Both NB-UVB and UVA1 phototherapy of PPP resulted in significant improvement. UVA1 phototherapy was more effective than NB-UVB irradiation in the treatment of PPP.