未经评估:心脏是高膳食盐摄入有害影响的重要靶器官。然而,高盐摄入对心肌活力的影响和关联,心功能变化,心肌重塑尚不清楚。
UNASSIGNED:从2008年4月至2010年11月以及从2019年8月至2019年11月,共有3,810名60岁及以上的参与者符合资格。使用连续7天的24小时尿液收集来估计盐摄入量。心肌应变率,心脏功能和结构,评估血清超敏C反应蛋白(hsCRP)水平。参与者被分类为低(n=643),轻度(n=989),中等(n=1,245),和高(n=933)组,对应于<6、6-9、9-12和>12克/天的盐摄入量,分别,取决于盐的摄入量估计。
UNASSIGNED:高组的整体舒张早期应变率(SRe)和舒张晚期应变率(SRa)分别为1.58±0.26、1.38±0.24。分别,与低点相比明显较低,温和,和中度组(均P<0.05)。高组的整体收缩期应变率(SRs)为-1.24±0.24,高于低组,温和,和中度组(均P<0.05)。盐摄入量与全球SR呈独立正相关,Tei指数,和左心室结构参数分别;与全局SRe和SRa呈负相关,左心室短轴缩短率,校正混杂因素后的左心室射血分数(所有P校正<0.001)。Hayes过程分析表明,hsCRP对全球SRe的中介作用,SRa,和SRs;Tei指数;和左心室重构指数为-0.013(95%CI:-0.015至-0.010),-0.010(-0.012至-0.008),0.008(0.006-0.010),0.005(0.003-0.006),和0.010(0.009-0.012),分别(所有P调整<0.001)。
UNASSIGNED:我们的数据表明,过量的盐摄入量与心肌活力和心脏功能的损害独立相关,以及心肌重塑。慢性炎症可能在高盐摄入与心功能损害和心肌重构之间的关系中起中介作用。
UNASSIGNED: The heart is an important target organ for the harmful effects of high dietary salt intake. However, the effects and associations of high salt intake on myocardial viability, cardiac function changes, and myocardial remodeling are unclear.
UNASSIGNED: A total of 3,810 participants aged 60 years and older were eligible and enrolled from April 2008 to November 2010 and from August 2019 to November 2019 in the Shandong area of
China. Salt intake was estimated using 24-h urine collection consecutively for 7 days. Myocardial strain rates, cardiac function and structure, and serum high-sensitivity C-reactive protein (hsCRP) levels were assessed. Participants were classified into low (n = 643), mild (n = 989), moderate (n = 1,245), and high (n = 933) groups, corresponding to < 6, 6-9, 9-12, and >12 g/day of salt intake, respectively, depending on the salt intake estimation.
UNASSIGNED: The global early diastolic strain rate (SRe) and late diastolic strain rate (SRa) in the high group were 1.58 ± 0.26, 1.38 ± 0.24. respectively, and significantly lower compared with the low, mild, and moderate groups (all P < 0.05). The global systolic strain rate (SRs) in the high group was -1.24 ± 0.24, and it was higher than those in the low, mild, and moderate groups (all P < 0.05). Salt intake was independently and positively correlated with global SRs, Tei index, and the parameters of left ventricular structure separately; negatively correlated with global SRe and SRa, left ventricular short axis shortening rate, left ventricular ejection fraction after adjusting for confounders (all P adjusted < 0.001). Hayes process analyses demonstrated that the mediating effects of hsCRP on global SRe, SRa, and SRs; Tei index; and left ventricular remodeling index were -0.013 (95% CI: -0.015 to -0.010), -0.010 (-0.012 to -0.008), 0.008 (0.006-0.010), 0.005 (0.003-0.006), and 0.010 (0.009-0.012), respectively (all P adjusted < 0.001).
UNASSIGNED: Our data indicate that excess salt intake is independently associated with the impairment in myocardial viability and cardiac function, as well as myocardial remodeling. Chronic inflammation might play a mediating role in the association between high salt intake and cardiac function damage and myocardial remodeling.