目的:研究1988年至2017年美国女性系统性红斑狼疮(SLE)死亡率黑白差异长期趋势的年龄差异。
方法:我们使用死亡率数据来计算1988年至2017年女性的年龄特异性SLE和全因(作为参考)死亡率和黑白死亡率。使用连接点回归分析估计年度百分比变化。
结果:我们确定了10,793和4,165,613名黑人女性以及19,455和31,129,528名白人女性,他们在1988年至2017年之间死于SLE和各种原因。分别。根据连接点回归模型,1988年0-24、25-44、45-64和65岁以上的死者的黑白SLE死亡率比率为6.6、7.2、4.4和1.4,2017年分别为7.2、5.9、4.1和1.9。没有发现明显的下降趋势,年度百分比变化为0.3%,-0.7%,-0.2%,和1.0%,分别。在对比中,黑/白全因死亡率比,1988年分别为2.0,2.5,1.8和1.0,2017年分别为1.7,1.3,1.5和0.9,各年龄组均有显著下降趋势.
结论:黑人成年人,青少年和青少年的SLE死亡率是白人的4至7倍,而且在过去30年中,黑白差异仍然存在.在对比中,黑人妇女的全因死亡率比白人妇女高不到两倍,并且在过去的三十年中,黑白差异显着缩小。
OBJECTIVE: To examine the age differences in secular trends in black-white disparities in mortality from systemic lupus erythematosus (SLE) among women in the United States from 1988 to 2017.
METHODS: We used mortality data to calculate age-specific SLE and all-causes (as reference) mortality rates and black/white mortality rates ratios among women from 1988 to 2017. Annual percent change was estimated using joinpoint regression analysis.
RESULTS: We identified 10,793 and 4,165,613 black women and 19,455 and 31,129,528 white women who died between 1988 and 2017 from SLE and all-causes, respectively. The black/white SLE mortality rate ratio according joinpoint regression model was 6.6, 7.2, 4.4, and 1.4 for decedents aged 0-24, 25-44, 45-64, and 65+ years in 1988 and was 7.2, 5.9, 4.1, and 1.9, respectively in 2017. No significant decline trend was noted and the annual percent change was 0.3%, -0.7%, -0.2%, and 1.0%, respectively. On the contrast, the black/white all-causes mortality rate ratio was 2.0, 2.5, 1.8, and 1.0, respectively in 1988 and was 1.7, 1.3, 1.5, and 0.9, respectively in 2017, a significant decline trend was noted in each age group.
CONCLUSIONS: Black adults, youths and adolescents had four to seven times higher SLE mortality rates than their white counterparts and the black-white disparities persisted during the past three decades. On the contrast, black women had less than two times higher all-causes mortality rates than their white counterparts and black-white disparities significantly diminish during the past three decades.