■主观认知功能下降(SCD)和轻度认知功能损害(MCI)是阿尔茨海默病(AD)的神经退行性加工阶段。认知下降被认为表现为内在的大脑活动变化,但是研究结果相互矛盾,很少有研究探索大脑区域在认知能力下降中的作用,以及认知领域对改变的内在大脑活动的变化的敏感性。
■在这项横断面研究中,从2019年7月至2021年5月,从南京医科大学第一附属医院记忆门诊招募158名老年受试者,分组为SCD(n=73),MCI(n=46),和正常对照(NC)(n=39)。计算并评估各组之间的低频波动幅度(ALFF)。然后进行典型相关分析(CCA)以研究影像学结果与认知行为之间的关联。
■不同认知维度和前额叶ALFF值的神经心理学测试,顶叶,和颞回,三组间差异有统计学意义(P<0.05),日常活动没有明显下降。内在活动的变化与认知功能的下降密切相关(R=0.73,P=0.002)。左枕中回ALFF值,右额中回,左额上回,左角回,颞上回在分析中发挥了重要作用,同时发现蒙特利尔认知评估(MoCA)和听觉语言学习测试得分对ALFF值的变化更敏感。
■自发性脑活动是认知障碍的稳定影像学生物标志物。前额叶的ALFF变化,枕骨,左角,颞回对识别认知能力下降很敏感,听觉语言学习测验和MoCA的分数可以预测异常的内在活动。
UNASSIGNED: Subjective cognitive decline (SCD) and mild cognitive impairment (MCI) are neurodegenerative processing stages of Alzheimer\'s disease (AD). Cognitive decline is thought to manifest in intrinsic brain activity changes, but research results yielded conflicting and few studies have explored the roles of brain regions in cognitive decline, and sensitivity of the cognitive field to changes in the altered intrinsic brain activity.
UNASSIGNED: In this cross-sectional study, 158 elderly participants were recruited from the memory clinic of the First Affiliated Hospital of Nanjing Medical University from July 2019 to May 2021, and grouped into SCD (n=73), MCI (n=46), and normal controls (NC) (n=39). The amplitude of low-frequency fluctuation (ALFF) was calculated and evaluated among the groups. Then canonical correlation analysis (CCA) was conducted to investigate the associations between imaging outcomes and cognitive behaviors.
UNASSIGNED: Neuropsychological tests in different cognitive dimensions and ALFF values of the prefrontal, parietal, and temporal gyrus, were significantly different (P<0.05) among the three groups, with no appreciable decline in daily activity. The changes in intrinsic activities were closely related to the decline in cognitive function (R=0.73, P=0.002). ALFF values in the left middle occipital gyrus, right middle frontal gyrus, left superior frontal gyrus, left angular gyrus, and superior temporal gyrus played significant roles in the analysis, while the Montreal Cognitive Assessment (MoCA) and Auditory-Verbal Learning Test scores were found to be more sensitive to changes in ALFF values.
UNASSIGNED: Spontaneous brain activity is a stable imaging biomarker of cognitive impairment. ALFF changes of the prefrontal, occipital, left angular, and temporal gyrus were sensitive to identifying cognitive decline, and the scores of the Auditory-Verbal Learning Test and MoCA could predict the abnormal intrinsic activities.