■炎症性肠病(IBD)可能与血液系统恶性肿瘤的发展有关。在这项研究中,我们研究了IBD与恶性血液病之间的潜在关系.
■我们搜索了PubMed,WebofScience,Embase,和CochraneLibrary数据库,用于比较非IBD人群与IBD患者血液系统恶性肿瘤的发病率的所有队列研究,并提取2000年1月至2023年6月的相关数据进行荟萃分析。
■本研究纳入了20项队列研究,涉及756,377名参与者。结果表明,与非IBD队列相比,IBD队列中恶性血液病的发生率较高(标准化发生率[SIR]=3.05,p<0.001).根据IBD的具体类型,与非IBD患者相比,溃疡性结肠炎患者(SIR=2.29,p=0.05)和克罗恩病患者(SIR=3.56,p=0.005)的恶性血液病发病率均较高.在血液系统恶性肿瘤类型的亚组分析中,与对照组相比,非霍奇金淋巴瘤的发病率(SIR=1.70,p=0.01),霍奇金淋巴瘤(SIR=3.47,p=0.002),在IBD队列中,白血病(SIR=3.69,p<0.001)均较高。
■血液系统恶性肿瘤的发病率,包括非霍奇金淋巴瘤,霍奇金淋巴瘤,IBD(溃疡性结肠炎或克罗恩病)患者的白血病高于非IBD患者。
UNASSIGNED: Inflammatory bowel disease (IBD) may contribute to the development of hematologic malignancies. In this study, the potential relationship between IBD and hematologic malignancies was investigated.
UNASSIGNED: We searched the PubMed, Web of Science, Embase, and Cochrane Library databases for all cohort studies comparing the incidence of hematologic malignancies in non-IBD populations with that in IBD patients, and we extracted relevant data from January 2000 to June 2023 for meta-analysis.
UNASSIGNED: Twenty cohort studies involving 756,377 participants were included in this study. The results showed that compared with the non-IBD cohort, the incidence of hematologic malignancies in the IBD cohort was higher (standardized incidence ratio [SIR]=3.05, p<0.001). According to the specific types of IBD, compared with the non-IBD patients, the incidences of hematologic malignancies in ulcerative colitis patients (SIR=2.29, p=0.05) and Crohn\'s disease patients (SIR=3.56, p=0.005) were all higher. In the subgroup analysis of hematologic malignancy types, compared with the control group, the incidences of non-Hodgkin\'s
lymphoma (SIR=1.70, p=0.01), Hodgkin\'s
lymphoma (SIR=3.47, p=0.002), and leukemia (SIR=3.69, p<0.001) were all higher in the IBD cohort.
UNASSIGNED: The incidence of hematologic malignancies, including non-Hodgkin\'s
lymphoma, Hodgkin\'s
lymphoma, and leukemia is higher in patients with IBD (ulcerative colitis or Crohn\'s disease) than in non-IBD patients.