■爱泼斯坦-巴尔病毒(EBV)是一种在人类中普遍存在的病毒。探讨EBV感染与肺癌发病风险的关系,以揭示其是否参与肺癌的发生发展。尽管过去已经讨论过EBV和肺癌。通过这项研究,我们希望加深对肺癌病因的认识,为肺癌的预防提供新的线索和目标,肺癌的早期诊断和治疗。这项研究也有利于医学科学和公共卫生的发展。首先,研究结果有望纳入肺癌预防和治疗策略和政策,从而为肺癌患者提供更好的治疗决策,提高患者的生存率和生活质量。同时,向公众传达研究结果有助于提高人们对肺癌危险因素的认识。通过鼓励健康的生活方式和筛查措施,公众可以降低患肺癌的风险。此外,本研究也为后续学术研究和科学探索提供了重要基础。为深入了解肺癌等相关领域提供了有价值的信息和启示。总的来说,这项研究对医学和公共卫生都有重要贡献。
■到2022年9月26日,使用在线数据库以英文进行文献检索。采用随机效应模型以95%置信区间(CI)估计EBV的患病率。此外,通过病例对照研究计算合并比值比(OR)和95CI,以确定EBV和肺癌之间的相关性.
■在这项886例肺癌患者的研究中,发现EBV感染的总体患病率为44.36%(95CI:4.08~16.9).14项研究被纳入分析,所有这些都使用了病例对照设计,并将肿瘤与邻近或非邻近的正常和非癌对照进行了比较。中国与其他地区肺癌组织中EBV感染的患病率存在显著差异,比值比(OR)为9.36(95%置信区间:4.00-21.94,P<0.001,I²=73.5%)。这表明EBV感染与肺癌病例之间的关联在中国比其他地区更强。此外,EBV感染的患病率因肺癌的不同病理类型而异,肺淋巴上皮瘤样癌(LELC)的发生率为81.08%,这是一种罕见的非小细胞肺癌(NSCLC)亚型。34.78%为非小细胞肺癌,小细胞肺癌为21.17%。统计分析表明,EBV感染与LELC的癌症风险最显著相关。而与小细胞肺癌相比,非小细胞肺癌与EBV的相关性更强。
■研究发现,EBV感染会使患肺癌的风险增加四倍以上,这种风险与病理类型有关,淋巴浸润,和肺癌的分化程度,特别是在非小细胞肺癌(NSCLC)的肺淋巴上皮瘤的罕见亚型中。此外,EBV感染的肺癌之间的相关性存在种族和地区差异,亚洲人口表现出更大的易感性。该研究使用肿瘤附近的正常或异常组织作为对照,这被认为是确定EBV感染与肺癌之间关系的更准确的方法。
UNASSIGNED: Epstein-Barr virus (EBV) is a virus that is ubiquitous in humans. To investigate the association between EBV infection and lung cancer risk to reveal whether it is involved in the development and development of lung cancer. Although there has been discussion of EBV and lung cancer in the past. Through this study, we hope to deepen our understanding of the causes of lung cancer and provide new clues and targets for the prevention, early diagnosis and treatment of lung cancer. This study is also beneficial to the development of medical science and public health. First of all, the research results are expected to be incorporated into lung cancer prevention and treatment strategies and policies, so as to provide better treatment decisions for lung cancer patients and improve the survival rate and quality of life of patients. At the same time, communicating the research results to the public can help raise awareness of lung cancer risk factors. By encouraging healthy lifestyles and screening measures, the public can reduce their risk of lung cancer. In addition, this study also provides an important foundation for subsequent academic research and scientific exploration. It provides valuable information and inspiration for in-depth understanding of lung cancer and other related fields. Overall, this study makes an important contribution to both medical science and public health.
UNASSIGNED: By September 26, 2022, an online database was used to conduct a literature search in English. Random effects models were employed to estimate the prevalence of EBV with 95% confidence intervals (CIs). Additionally, the pooled odds ratio (OR) and 95%CI were calculated from case-control studies to determine the association between EBV and lung cancer.
UNASSIGNED: In this study of 886 patients with lung cancer, the overall prevalence of EBV infection was found to be 44.36% (95%CI: 4.08-16.9). Fourteen studies were included in the analysis, all of which used a case-control design and involved comparisons of tumors with adjacent or non-adjacent normal and non-cancerous controls. There was a significant difference in the prevalence of EBV infection in lung cancer tissues between
China and other regions, with an odds ratio (OR) of 9.36 (95% confidence interval: 4.00-21.94, P<0.001, I²=73.5%). This suggests that the association between EBV infection and lung cancer cases is stronger in
China than in other regions. Additionally, the prevalence of EBV infection varied across different pathological types of lung cancer, with rates of 81.08% for pulmonary lymphoepithelioma-like carcinoma (LELC),this a rare subtype of non-small cell lung cancer (NSCLC).34.78% for non-small cell lung cancer, and 21.17% for small cell lung cancer. The statistical analysis indicated that EBV infection was most significantly associated with cancer risk in LELC, while non-small cell lung cancer was more strongly associated with EBV than small cell lung cancer.
UNASSIGNED: The study found that EBV infection increases the risk of lung cancer by more than four times, and this risk is associated with the pathological type, lymphatic infiltration, and degree of differentiation of the lung cancer, particularly in the rare subtype of pulmonary lymphoepithelioma in non-small cell lung cancer(NSCLC). Additionally, there are racial and regional differences in the correlation between EBV-infected lung cancer, with the Asian population showing greater susceptibility. The study used normal or abnormal tissue adjacent to the tumor as a control, which is considered a more accurate method for determining the relationship between EBV infection and lung cancer.