隐藏在宿主细胞中的细胞内细菌病原体耐受先天免疫系统和高剂量抗生素，导致难以治疗的复发性感染。在这里，一种归巢式导弹状纳米治疗剂(FeSAs@Sa。M）由单原子铁纳米酶（FeSAs）核心组成，该核心包被有感染的巨噬细胞膜（Sa。M）被开发用于原位消除细胞内耐甲氧西林金黄色葡萄球菌（MRSA）。机械上,FeSAs@Sa。M最初通过Sa的细菌识别能力与细胞外MRSA结合。M分量。随后，FeSAs@Sa。M可以在其附着的细胞外MRSA的引导下，像归巢导弹一样转运到宿主细胞内MRSA定位区域，通过FeSAs核心的酶活性产生高毒性的活性氧（ROS）用于杀死细胞内MRSA。TheFeSAs@Sa.M在杀死细胞内MRSA方面远远优于FeSA，提出了一种通过在细菌驻留区域原位产生ROS来治疗细胞内感染的可行策略。
Intracellular bacterial pathogens hiding in host cells tolerate the innate immune system and high-dose antibiotics, resulting in recurrent infections that are difficult to treat. Herein, a homing missile-like nanotherapeutic (FeSAs@Sa.M) composed of a single-atom iron nanozyme (FeSAs) core coated with infected macrophage membrane (Sa.M) is developed for in situ elimination of intracellular methicillin-resistant S. aureus (MRSA). Mechanically, the FeSAs@Sa.M initially binds to the extracellular MRSA via the bacterial recognition ability of the Sa.M component. Subsequently, the FeSAs@Sa.M can be transported to the intracellular MRSA-located regions in the host cell like a homing missile under the guidance of the extracellular MRSA to which it is attached, generating highly toxic reactive oxygen species (ROS) for intracellular MRSA killing via the enzymatic activities of the FeSAs core. The FeSAs@Sa.M is far superior to FeSAs in killing intracellular MRSA, proposing a feasible strategy for treating intracellular infections by in situ generating ROS in bacterial residing regions.
