目的:人多能干细胞,包括胚胎干细胞和诱导多能干细胞,为退行性疾病和细胞修复提供突破性的治疗潜力。尽管意义重大,在这一领域进行了全面的文献计量分析,特别是与年龄相关的黄斑变性(AMD),尚未进行。本研究旨在通过文献计量分析绘制干细胞和AMD研究的基础和新兴领域。
方法:本研究分析了2000年至2022年有关干细胞和AMD的文章和评论,来自WebofScienceCoreCollection。我们使用VOSviewer和CiteSpace来分析和可视化与国家有关的数据,机构,作者,期刊,参考文献和关键词。使用R语言和MicrosoftExcel365进行统计分析。
结果:总计,包括539种出版物,表明从2000年到2022年,关于干细胞和AMD的全球文献有所增加。美国是主要的贡献者,有239篇论文和最高的H指数,此外,美国每篇文章的平均引用率最高(59.82)。值得注意的是,前十大机构中有50%来自美国,加州大学系统是最有生产力的。主要作者包括高桥雅雄,美智子曼代,丹尼斯·克莱格,PeteJ.Coffey,BorisStanzel,还有BuddA.Tucker.调查眼科和视觉科学发表了大多数相关论文(n=27)。关键词如“临床试验,干细胞疗法,“\”视网膜类器官,“和”视网膜祖细胞“占优势。
结论:关于干细胞和AMD的研究取得了显著进展,强调加强全球合作的必要性。当前的研究优先考虑了“ipsc”之间的关系,诱导多能干细胞,“\”细胞培养,“和”人类胚胎干细胞。“随着干细胞培养和安全性的进步,焦点已经转移到移植后的预后和并发症,标志着干细胞研究从实验室到临床环境的运动。
Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, offer groundbreaking therapeutic potential for degenerative diseases and cellular repair. Despite their significance, a comprehensive bibliometric analysis in this field, particularly in relation to age-related macular degeneration (AMD), is yet to be conducted. This study aims to map the foundational and emerging areas in stem cell and AMD research through bibliometric analysis.
This study analyzed articles and reviews on stem cells and AMD from 2000 to 2022, sourced from the Web of Science Core Collection. We used VOSviewer and CiteSpace for analysis and visualization of data pertaining to countries, institutions, authors, journals, references and key words. Statistical analyses were conducted using R language and Microsoft Excel 365.
In total, 539 publications were included, indicating an increase in global literature on stem cells and AMD from 2000 to 2022. The USA was the leading contributor, with 239 papers and the highest H-index, also the USA had the highest average citation rate per article (59.82). Notably, 50% of the top 10 institutions were from the USA, with the University of California system being the most productive. Key authors included Masayo Takahashi, Michiko Mandai, Dennis Clegg, Pete J. Coffey, Boris Stanzel, and Budd A. Tucker. Investigative Ophthalmology & Visual Science published the majority of relevant papers (n = 27). Key words like \"clinical trial,\" \"stem cell therapy,\" \"retinal organoid,\" and \"retinal progenitor cells\" were predominant.
Research on stem cells and AMD has grown significantly, highlighting the need for increased global cooperation. Current research prioritizes the relationship between \"ipsc,\" \"induced pluripotent stem cell,\" \"cell culture,\" and \"human embryonic stem cell.\" As stem cell culture and safety have advanced, focus has shifted to prognosis and complications post-transplantation, signifying the movement of stem cell research from labs to clinical settings.