■目前,儿童甲状腺癌领域的知识结构还不够清晰,学者们对这一领域的发展趋势缺乏足够的了解,这导致了前瞻性产出的短缺。这项研究的目的是帮助学者构建一个完整的知识框架,并识别当前的挑战,机遇,和发展趋势。
■我们于2023年8月7日在WebofScienceCoreCollection数据库中搜索了文献,并从引用最多的前100篇文章中提取了关键信息,比如国家,机构,作者,主题,和关键词。我们使用了文献计量学工具,如文献计量学,VOSviewer,和CiteSpace用于可视化分析,Excel用于统计描述。
■引用次数最多的前100篇文章随时间波动,研究集中在欧洲国家,美国,和日本,其中美国的科研机构和学者做出了突出贡献。关键字分析显示,研究已从小儿甲状腺癌(甲状腺全切除术)和诱发因素(切尔诺贝利电站事故)的简单治疗方法转变为基因突变(例如BRAF和RET基因)的临床应用和更大规模的遗传变化(DICER1基因的突变研究)。主题策略分析显示融合癌基因的流行趋势日益增加,而传统治疗和诊断研究的普及逐渐下降。
■对小儿甲状腺癌的基本问题进行了广泛的研究,在常规诊断和治疗方法的随访和队列分析中,有显著的结果。然而,这些方法仍有一定的局限性。因此,学者们应该专注于探索融合基因,分子靶点的临床应用,和新颖的治疗方法。本研究为该领域的学者提供了有力的参考。
UNASSIGNED: At present, the structure of knowledge in the field of childhood thyroid cancer is not clear enough, and scholars lack a sufficient understanding of the developing trends in this field, which has led to a shortage of forward-looking outputs. The purpose of this research is to help scholars construct a complete knowledge framework and identify current challenges, opportunities, and development trends.
UNASSIGNED: We searched the literature in the Web of Science Core Collection database on August 7, 2023 and extracted key information from the top 100 most cited articles, such as the countries, institutions, authors, themes, and keywords. We used bibliometric tools such as bibliometrix, VOSviewer, and CiteSpace for a visualization analysis and Excel for statistical descriptions.
UNASSIGNED: The top 100 most cited articles fluctuated over time, and the research was concentrated in European countries, the United States, and Japan, among which scientific research institutions and scholars from the United States made outstanding contributions. Keyword analysis revealed that research has shifted from simple treatment methods for pediatric thyroid cancer (total thyroidectomy) and inducing factors (the Chernobyl power station accident) to the clinical applications of genetic mutations (such as the BRAF and RET genes) and larger-scale genetic changes (mutation studies of the DICER1 gene). The thematic strategy analysis showed an increasing trend towards the popularity of fusion oncogenes, while the popularity of research on traditional treatments and diagnostics has gradually declined.
UNASSIGNED: Extensive research has been conducted on the basic problems of pediatric thyroid cancer, and there has been significant outputs in the follow-up and cohort analysis of conventional diagnostic and treatment methods. However, these methods still have certain limitations. Therefore, scholars should focus on exploring fusion genes, the clinical applications of molecular targets, and novel treatment methods. This study provides a strong reference for scholars in this field.