■在中国,尚未在一项基于人群的研究中对产前诊断为先天性心脏病(CHD)的胎儿的结局进行调查。这项基于人群的研究旨在评估青岛地区单纯性CHD产前诊断后自愿终止妊娠率。中国。
■这是一项基于人群的回顾性研究,收集了2018年8月至2020年7月青岛(中国东部)所有孕妇的数据;胎儿数据,我们从有关CHD产前诊断的医疗记录中提取了孕产妇数据和妊娠结局数据.纳入标准为:户籍在青岛的孕妇或其丈夫,在青岛进行定期产前筛查。排除标准是未能签署知情同意书。由经验丰富的儿科心脏病专家组成的多学科团队为冠心病胎儿的所有父母提供咨询,产科医生,遗传学家,等。根据冠心病的类型和严重程度,分析终止妊娠率。
■在126,843名孕妇中,该研究包括1299例产前诊断为CHD的胎儿。在包括的胎儿中,1075例被诊断为单纯性冠心病,总体终止妊娠率为22.8%。终止率根据CHD的复杂性而变化(低复杂性与中等复杂性,P=0.000;低复杂度与高复杂度,P=0.000;中等复杂度与高复杂度,P=0.000),低复杂度的比率为6.0%,54.2%为中等复杂度,和99.1%的高复杂度。单发冠心病患者终止妊娠的决定与母亲年龄无关(P=0.091),但与孕龄有关(P=0.000)。
■在青岛,99.1%的胎儿被诊断为孤立的高复杂性CHD的父母选择自愿终止妊娠。妊娠终止率随着产前诊断冠心病的复杂性增加而增加。
UNASSIGNED: The outcomes of fetuses with isolated congenital heart disease (CHD) diagnosed prenatally have not been investigated in a population-based study in
China. This population-based study aimed to evaluate the rate of voluntary termination of pregnancy after the prenatal diagnosis of isolated CHD in Qingdao,
China.
UNASSIGNED: This was a population-based retrospective study in which data were collected from all pregnant women in Qingdao (eastern
China) from August 2018 to July 2020; fetal data, maternal data and data on pregnancy outcomes were extracted from medical records regarding prenatal diagnosis of CHD. The inclusion criteria were as follows: pregnant women or their husbands who had a household registration in Qingdao and who underwent regular prenatal screening in Qingdao. The exclusion criterion was the failure to sign an informed consent form. Counseling for all parents of fetuses with CHD was provided by a multidisciplinary team of experienced pediatric cardiologists, obstetricians, geneticists, etc. According to the type and severity of CHD, the pregnancy termination rate was analyzed.
UNASSIGNED: Among the 126,843 pregnant women, 1299 fetuses with a prenatal diagnosis of CHD were included in the study. Among the included fetuses, 1075 were diagnosed with isolated CHD, and the overall pregnancy termination rate was 22.8%. Termination rates varied according to the complexity of CHD (low complexity vs moderate complexity, P=0.000; low complexity vs high complexity, P=0.000; moderate complexity vs high complexity, P=0.000), with rates of 6.0% for low complexity, 54.2% for moderate complexity, and 99.1% for high complexity. The decision to terminate the pregnancy in cases of isolated CHD was unrelated to maternal age (P=0.091) but was related to gestational age (p=0.000).
UNASSIGNED: In Qingdao, 99.1% of parents whose fetuses were diagnosed with isolated high-complexity CHD chose to voluntarily terminate the pregnancy. The pregnancy termination rate increased with increasing complexity of prenatally diagnosed CHD.