人类类器官的出现和快速发展为替代动物模型治疗人类疾病提供了可能。情报研究有助于关注研究热点并解决关键的机械问题。目前,很少有全面的研究描述人类类器官研究的特征。在这项研究中,在过去的二十年中,我们从WebofScience核心收集数据库中提取了8,591篇有关类器官的原始文章,并使用CiteSpace进行了情报分析。在过去十年中,该领域的出版物数量迅速增长(自2009年以来几乎增加了70倍)。美国,中国,德国,荷兰,和英国在发表文章方面有很强的合作。聪明的汉斯,VanDerLaan,JasonRSpence,佐藤敏郎为推动这一领域的进展做出了重大贡献。聚类和爆发分析将研究热点分类为组织模型和功能构建,细胞间信号,免疫机制,和肿瘤转移。高被引文章中的类器官研究涵盖四个主要领域:基础研究(38%),涉及干细胞发育过程和细胞-细胞相互作用;生物基线(10%),专注于类器官培养;精准医学(16%),强调细胞治疗和药物开发;和疾病建模(36%),包括病原体分析和疾病相关遗传变异的筛查。目前在类器官研究中面临的主要障碍包括成本和技术,细胞的血管化,免疫系统的建立,国际标准协议,以及高质量临床试验数据的可用性有限。未来的研究将集中在节约成本的措施上,技术共享,国际标准的发展,进行高水平的临床试验.
The emergence and rapid development of human organoids have provided the possibility to replace animal models in treating human diseases. Intelligence studies help focus on research hotspots and address key mechanistic issues. Currently, few comprehensive studies describe the characteristics of human organoid research. In this study, we extracted 8,591 original articles on organoids from the Web of Science core collection database over the past two decades and conducted intelligence analysis using CiteSpace. The number of publications in this field has experienced rapid growth in the last ten years (almost 70-fold increase since 2009). The United States,
China, Germany, Netherlands, and UK have strong collaborations in publishing articles. Clevers Hans, Van Der Laan, Jason R Spence, and Sato Toshiro have made significant contributions to advancing progress in this field. Clustering and burst analysis categorized research hotspots into tissue model and functional construction, intercellular signaling, immune mechanisms, and tumor metastasis. Organoid research in highly cited articles covers four major areas: basic research (38%), involving stem cell developmental processes and cell-cell interactions; biobanking (10%), with a focus on organoid cultivation; precision medicine (16%), emphasizing cell therapy and drug development; and disease modeling (36%), including pathogen analysis and screening for disease-related genetic variations. The main obstacles currently faced in organoid research include cost and technology, vascularization of cells, immune system establishment, international standard protocols, and limited availability of high-quality clinical trial data. Future research will focus on cost-saving measures, technology sharing, development of international standards, and conducting high-level clinical trials.