目的:中枢神经系统(CNS)肿瘤是全世界儿童最常见的实体恶性肿瘤,包括亚美尼亚。本研究旨在分析流行病学数据,治疗,在过去的26年中,亚美尼亚儿童和年轻人(≤25岁)患有中枢神经系统肿瘤的结局。
方法:我们收集了1995年1月1日至2020年12月31日在亚美尼亚选定地点接受治疗的儿童和年轻成人患者的数据。按性别分列的发病率,诊断时的年龄,从第一次投诉到诊断的时间,组织病理学结果,治疗策略,并发症,计算总生存率(OS)。
结果:多中心数据分析显示,在26年的时间里,有149例患者被诊断为原发性中枢神经系统肿瘤。其中,84(56.4%)为男性。诊断时的中位年龄为7岁(范围,3个月至25年),从第一次投诉到诊断的中位时间为2个月(范围,1周至70个月)。髓母细胞瘤和其他胚胎性肿瘤(47),低级别胶质瘤(32),高级别胶质瘤(22)是最常见的恶性肿瘤。室管膜瘤,颅咽管瘤,生殖细胞肿瘤,在22例患者中观察到其他恶性肿瘤。对于26名患者,没有组织病理学或放射学诊断.98例(65.8%)患者获得了随访信息。整个研究组的5年OS率为67.7%。
结论:与国际数据一致,胚胎性肿瘤,神经胶质瘤是亚美尼亚最常见的中枢神经系统恶性肿瘤。在研究期间,亚美尼亚往往无法获得多模式治疗,尤其是早期病例。
OBJECTIVE: Central nervous system (CNS) tumors are the most common solid malignancies in children worldwide, including in Armenia. The current study aims to analyze epidemiological data, treatment, and outcomes of children and young adults (≤25 years) with CNS tumors in Armenia during the last 26 years.
METHODS: We collected data from pediatric and young adult patients treated in selected sites in Armenia from 1st January 1995 to 31st December 2020. Incidence by sex, age at diagnosis, time from first complaints to diagnosis, histopathology results, treatment strategies, complications, and overall survival (OS) rates were calculated.
RESULTS: The multicenter data analysis revealed 149 patients with diagnosed primary CNS tumors over 26 years. Among them, 84 (56.4%) were male. The median age at diagnosis was 7 years (range, 3 months to 25 years), and the median time from the first complaints to diagnosis was 2 months (range, 1 week to 70 months). Medulloblastomas and other embryonal tumors (47), low-grade gliomas (32), and high-grade gliomas (22) were the most commonly diagnosed malignancies. Ependymomas, craniopharyngiomas, germ cell tumors, and other malignancies were observed in 22 patients. For 26 patients, no histopathological or radiological diagnosis was available. Follow-up information was available for 98 (65.8%) patients. The 5-year OS rate for the whole study group was 67.7%.
CONCLUSIONS: Consistent with international data, embryonal tumors, and gliomas were the most commonly diagnosed CNS malignancies in Armenia. Multimodal treatment was often not available in Armenia during the study period, especially for early cases.