UNASSIGNED:由于与冠状病毒疾病相关的发病率和死亡率较高,心脏损伤受到了相当大的关注。然而,在发展中国家,缺乏与炎症生物标志物相关的COVID-19患者心脏损伤的数据.
UNASSIGNED:因此,本研究回顾性分析了巴基斯坦旁遮普省三家地区医院的数据,以调查心脏损伤对COVID-19感染患者死亡率和严重程度的潜在影响。我们在2022年1月16日至4月18日期间评估了2,051例确诊为COVID-19的患者。所选样本量记录的住院死亡率约为16.28%。
UNASSIGNED:大多数参与者被确定为男性(64%),中位年龄为65岁。此外,发烧,疲劳,和呼吸困难被报告为常见症状。623名患者(30.38%)有心脏损伤,当这些患者与没有心脏损伤的患者相比时,参与者明显年龄较大,合并疾病较多,白细胞计数较高,C反应蛋白水平升高,白细胞介素-6,降钙素原,肌红蛋白,肌酐激酶-心肌带,血清肌酐,高灵敏度肌钙蛋白-I,在影像学检查结果中,N末端B型利钠肽前体有大量的多磨玻璃混浊和双侧肺浸润。与没有心脏损伤的参与者相比,有心脏损伤的参与者需要更多的非侵入性或侵入性机械呼吸。心脏损伤患者败血症发生率较高,急性呼吸窘迫综合征(ARDS),D-二聚体浓度,和呼吸衰竭比那些没有心脏损伤。心脏损伤患者的死亡率高于未遭受心脏损伤的患者。在多变量逻辑回归分析中,患有心脏损伤的参与者显示出更大的COVID-19死亡几率,并且与年龄相关(OR=1.99,95%CI=0.04-3.19),心肌肌钙蛋白I升高(OR=18.64,95%CI=13.16-23.01),合并脓毒症(OR=10.39,95%CI=7.41~13.39)和ARDS(OR=6.65,95%CI=4.04~8.91)。
UNASSIGNED:心脏损伤是旁遮普邦冠状病毒感染患者的常见并发症,巴基斯坦,它与更大的院内死亡风险显著相关。
UNASSIGNED: Cardiac injury has received considerable attention due to the higher risk of morbidity and mortality associated with coronavirus disease. However, in a developing country, there is a scarcity of data on cardiac injury in COVID-19 patients related to inflammatory biomarkers.
UNASSIGNED: Therefore, the present research retrospectively analyzes data from three territorial hospitals in Pakistan\'s Punjab province to investigate the potential impact of the cardiac injury on the mortality and severity of COVID-19-infected patients. We evaluated 2,051 patients between January 16 and April 18, 2022, with confirmed COVID-19. The in-hospital mortality recorded for the selected sample size was about 16.28%.
UNASSIGNED: The majority of the participants were identified as male (64%) with a median age of 65 years. Also, fever, fatigue, and dyspnea were reported as common symptoms. An aggregate of 623 patients (30.38%) had a cardiac injury, and when these patients are compared to those without cardiac injury, the participants were significantly older and had more comorbidities with higher leukocyte counts, elevated levels of C-reactive protein, interleukin-6, procalcitonin, myohemoglobin, creatinine kinase-myocardial band, serum creatinine, high-sensitivity troponin-I, N-terminal pro-B-type natriuretic peptide had a significant amount of multiple ground-glass opacity and bilateral pulmonary infiltration in radiographic results. Participants with heart injury required more non-invasive or invasive mechanical respiration than those who did not have a cardiac injury. Individuals with cardiac injury had higher rates of sepsis, acute respiratory distress syndrome (ARDS), d-dimer concentration, and respiratory failure than those without cardiac injury. Patients who had had a cardiac injury died at a higher rate than those who had not suffered cardiac damage. In the multivariable logistic regression analysis, participants with cardiac injury showed greater odds of COVID-19 mortality and were found associated with older age (OR = 1.99, 95% CI = 0.04-3.19), elevated cardiac troponin I (OR = 18.64, 95% CI = 13.16-23.01), the complication of sepsis (OR = 10.39, 95% CI = 7.41-13.39) and ARDS (OR = 6.65, 95% CI = 4.04-8.91).
UNASSIGNED: Cardiac injury is a frequent complication among patients with coronavirus-induced infection in Punjab, Pakistan, and it is significantly linked to a greater risk of in-hospital mortality.