这项研究旨在探索医生和药剂师的知识,态度,和实践(KAP)关于预防和治疗与癌症治疗相关的心血管毒性。一项多中心横断面研究包括2023年4月至2023年6月期间的医生和药剂师。该研究包括918名参与者(514名医生和404名药剂师)。知识的平均得分,态度,练习分别为11.6±3.39、24.7±2.6和26.3±6.8分。足够的知识与年龄≥41岁(优势比(OR)=2.745,95%置信区间(CI)1.086-6.941,P=0.033),男性(OR=2.745,95%CI1.150-2.223,P=0.005),学士学位(OR=0.084,95%CI0.013-0.533,P=0.009),硕士及以上学历(OR=0.096,95%CI0.015-0.609,P=0.013),医生职业(OR=7.601,95%CI1.337-43.207,P=0.022),药剂科(OR=18.858,95%CI3.245-109.57,P=0.001),肿瘤科(OR=4.304,95%CI2.426-7.634,P<0.001),心内科(OR=3.001,95%CI1.387-6.492,P=0.005),位于华东地区的医院(OR=1.957,95%CI1.120-3.418,P=0.018),和位于中国西部的医院(OR=3.137,95%CI1.783-5.518,P<0.001)。积极态度与高级职称(OR=2.989,95%CI1.124-7.954,P=0.028)和位于华东地区的医院(OR=0.424,95%CI0.257-0.698,P=0.001)显着相关。西部地区(OR=0.231,95%CI0.136-0.394,P<0.001),和华南地区(OR=0.341,95%CI0.198-0.587,P<0.001)。积极实践与男性显著相关(OR=1.414,95%CI1.029-1.943,P=0.033),高级职称(OR=3.838,95%CI1.176-12.524,P=0.026),肿瘤科(OR=3.827,95%CI2.336-6.272,P<0.001),和心内科(OR=2.428,95%CI1.263-4.669,P=0.008)。医生和药剂师对预防和治疗与癌症治疗相关的心血管毒性反应持积极态度。而他们的知识和实践并不那么积极主动。
This study aimed to explore physicians\' and pharmacists\' knowledge, attitudes, and practice (KAP) regarding the prevention and treatment of cardiovascular toxicity associated with cancer treatment. A multicenter cross-sectional study included physicians and pharmacists between April 2023 and June 2023. The study included 918 participants (514 physicians and 404 pharmacists). The average scores of knowledge, attitudes, and practice were 11.6 ± 3.39, 24.7 ± 2.6, and 26.3 ± 6.8 points. Sufficient knowledge was significantly associated with age ≥ 41 years (odds ratio (OR) = 2.745, 95% confidence interval (CI) 1.086-6.941, P = 0.033), male (OR = 2.745, 95% CI 1.150-2.223, P = 0.005), bachelor\'s degree (OR = 0.084, 95% CI 0.013-0.533, P = 0.009), master\'s degree and above (OR = 0.096, 95% CI 0.015-0.609, P = 0.013), physician occupation (OR = 7.601, 95% CI 1.337-43.207, P = 0.022), pharmacy department (OR = 18.858, 95% CI 3.245-109.57, P = 0.001), oncology department (OR = 4.304, 95% CI 2.426-7.634, P < 0.001), cardiology department (OR = 3.001, 95% CI 1.387-6.492, P = 0.005), hospitals located in Eastern
China (OR = 1.957, 95% CI 1.120-3.418, P = 0.018), and hospitals located in Western
China (OR = 3.137, 95% CI 1.783-5.518, P < 0.001). Positive attitudes were significantly associated with a senior professional title (OR = 2.989, 95% CI 1.124-7.954, P = 0.028) and hospitals located in Eastern
China (OR = 0.424, 95% CI 0.257-0.698, P = 0.001), Western
China (OR = 0.231, 95% CI 0.136-0.394, P < 0.001), and Southern
China (OR = 0.341, 95% CI 0.198-0.587, P < 0.001). Proactive practice was significantly associated with male (OR = 1.414, 95% CI 1.029-1.943, P = 0.033), senior professional title (OR = 3.838, 95% CI 1.176-12.524, P = 0.026), oncology department (OR = 3.827, 95% CI 2.336-6.272, P < 0.001), and cardiology department (OR = 2.428, 95% CI 1.263-4.669, P = 0.008). Both physicians and pharmacists had positive attitudes toward the prevention and treatment of cardiovascular toxicity associated with cancer treatment, while their knowledge and practice were not as proactive.