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Abstract：
Extensive efforts have been dedicated to exploring the impact of tumor heterogeneity on cancer treatment at both histological and genetic levels. To accurately measure intra-tumoral heterogeneity, a non-invasive imaging technique, known as habitat imaging, was developed. The technique quantifies intra-tumoral heterogeneity by dividing complex tumors into distinct sub- regions, called habitats. This article reviews the following aspects of habitat imaging in cancer treatment, with a focus on radiotherapy: (1) Habitat imaging biomarkers for assessing tumor physiology; (2) Methods for habitat generation; (3) Efforts to combine radiomics, another imaging quantification method, with habitat imaging; (4) Technical challenges and potential solutions related to habitat imaging; (5) Pathological validation of habitat imaging and how it can be utilized to evaluate cancer treatment by predicting treatment response including survival rate, recurrence, and pathological response as well as ongoing open clinical trials.
摘要：
已经进行了广泛的努力来探索肿瘤异质性在组织学和遗传水平上对癌症治疗的影响。为了准确测量肿瘤内异质性，一种非侵入性成像技术，被称为栖息地成像，已开发。该技术通过将复杂肿瘤分为不同的子区域来量化肿瘤内异质性，叫做栖息地。本文综述了栖息地成像在癌症治疗中的以下几个方面，以放射治疗为重点：（1）用于评估肿瘤生理学的生境成像生物标志物；（2）生境生成方法；（3）努力结合放射组学，另一种成像量化方法，（4）与栖息地成像相关的技术挑战和潜在解决方案；（5）栖息地成像的病理学验证以及如何通过预测治疗反应（包括生存率）来评估癌症治疗，复发,和病理反应以及正在进行的开放临床试验。
