2,4-二硝基苯酚(2,4-DNP),一种淡黄色的化合物,历史上一直被用于制造染料,炸药,和杀菌剂。当它解耦线粒体氧化磷酸化时,该化合物在上个世纪初也被用作抗肥胖药。该化合物随后于1938年被美国食品和药物管理局禁止,因为其潜在的致命副作用,包括热疗,白内障,粒细胞缺乏症,肝毒性,肾毒性,和心脏毒性。然而,近年来,2,4-DNP作为减肥助剂的普及似乎再次增加。香港医院管理局毒理学参考实验室最近向该地区的医院确认了两例自我给药的2,4-DNP,其临床表现不同。在这里我们描述这两种情况,试图强调中国人群中有意识的群体滥用这种物质的可能性。
2,4-Dinitrophenol (2,4-DNP), a yellowish compound, has historically been used in the manufacture of dyes, explosives, and fungicides. As it uncouples mitochondrial oxidative phosphorylation, the compound was also used as an antiobesity agent early in the past century. The compound was subsequently banned by the United States Food and Drug Administration in 1938 due to its potentially fatal adverse effects, including hyperthermia, cataract, agranulocytosis, hepatoxicity, nephrotoxicity, and cardiotoxicity. However, the popularity of 2,4-DNP as a slimming aid has appeared to increase again in recent years. The Hong Kong Hospital Authority Toxicology Reference Laboratory recently confirmed two cases of self-administered 2,4-DNP with different clinical presentations to hospitals in the area. Here we describe those two cases, in an attempt to underscore the potential of misuse of this substance by body-conscious groups among the Chinese population.