目的:先前的研究表明,重度抑郁症(MDD)与某些合并症之间存在联系,包括肠胃问题,甲状腺功能障碍,糖脂代谢异常.然而,这些因素与成人MDD患者功能连接(FC)不对称改变之间的关系尚不清楚.
方法:我们对42名MDD患者和42名健康对照(HC)进行了一项研究。参与者接受了全面的临床评估,包括血脂和甲状腺激素水平的评估,以及静息状态功能磁共振成像(Rs-fMRI)扫描。数据分析涉及相关分析,以计算整个大脑功能连接体的不对称参数(PAS)。然后我们检查了大脑中异常PAS区域之间的相互关系,甲状腺激素水平,和血脂水平。
结果:发现第三代超敏感甲状腺刺激激素(TSH3UL)水平在MDD患者中明显低于HCs。左额下回(IFG)PAS评分降低,而MDD患者的双侧后扣带回皮质(Bi-PCC)PAS相对于HCs增加。值得注意的是,左侧IFG的PAS评分与TSH和总胆固醇(CHOL)水平呈负相关。然而,这些相关性在Bonferroni校正后失去了意义。
结论:MDD患者在额边缘系统内的静息状态FC(Rs-FC)表现出异常不对称,这可能与CHOL和甲状腺激素水平有关。
OBJECTIVE: Previous research has suggested a connection between major depressive disorder (MDD) and certain comorbidities, including gastrointestinal issues, thyroid dysfunctions, and glycolipid metabolism abnormalities. However, the relationships between these factors and asymmetrical alterations in functional connectivity (FC) in adults with MDD remain unclear.
METHODS: We conducted a study on a cohort of 42 MDD patients and 42 healthy controls (HCs). Participants underwent comprehensive clinical assessments, including evaluations of blood lipids and thyroid hormone levels, as well as resting-state functional magnetic resonance imaging (Rs-fMRI) scans. Data analysis involved correlation analysis to compute the parameter of
asymmetry (PAS) for the entire brain\'s functional connectome. We then examined the interrelationships between abnormal PAS regions in the brain, thyroid hormone levels, and blood lipid levels.
RESULTS: The third-generation ultra-sensitive thyroid stimulating hormone (TSH3UL) level was found to be significantly lower in MDD patients compared to HCs. The PAS score of the left inferior frontal gyrus (IFG) decreased, while the bilateral posterior cingulate cortex (Bi-PCC) PAS increased in MDD patients relative to HCs. Notably, the PAS score of the left IFG negatively correlated with both TSH and total cholesterol (CHOL) levels. However, these correlations lose significance after the Bonferroni correction.
CONCLUSIONS: MDD patients demonstrated abnormal
asymmetry in resting-state FC (Rs-FC) within the fronto-limbic system, which may be associated with CHOL and thyroid hormone levels.