藻类及其提取物,作为功能性食品广泛食用,提供许多健康益处;然而,目前缺乏对临床证据的全面系统总结。该研究旨在评估现有证据,并准确估计藻类及其提取物补充剂对各种健康结果的总体影响。PubMed中的全面搜索,Scopus,Embase,WebofScience,并在2023年12月22日之前实施了Cochrane图书馆。使用Stata软件采用随机效应模型来汇集总体效应大小(ES)和相应的95%置信区间(CI)。此外,通过A测量工具评估系统评价2(AMSTAR2)和建议评估开发和评估的分级,检测合格研究的方法学质量和证据水平.最终,这项总括审查包括25篇涵盖133项健康结果的文章。汇总结果表明,藻类及其提取物可以显着降低体重(ES=-1.65;95%CI:-1.97,-1.34;p<0.001),体重指数(BMI)(ES=-0.42;95%CI:-0.78,-0.07;p=0.020),腰围(WC)(ES=-1.40;95%CI:-1.40,-1.39;p<0.001),甘油三酯(TG)(ES=-1.38;95%CI:-2.15,-0.62;p<0.001),总胆固醇(TC)(ES:-1.40;95%CI:-2.09,-0.72;p<0.001),极低密度脂蛋白胆固醇(VLDL-C)(ES=-7.85;95%CI:-8.55,-7.15;p<0.001),空腹血糖(ES=-2.68;95%CI:-4.57,-0.79;p=0.005),糖化血红蛋白(HbA1c)(ES=-0.15;95%CI:-0.24,-0.07;p<0.001),收缩压(ES=-3.21;95%CI:-5.25,-1.17;p=0.002),舒张压(ES=-3.84;95%CI:-7.02,-0.65;p=0.018),丙氨酸转氨酶(ES=-0.42;95%CI:-0.70,-0.14;p=0.003),和碱性磷酸酶(ES=-0.54;95%CI:-0.99,-0.10;p=0.017)。由于研究数量有限,未显示炎症和氧化应激标志物的获益.考虑到研究质量欠佳,以及与某些结果相关的文章不足,进一步精心设计的研究必须证实观察到的发现。
Algae and its extracts, widely consumed as functional foods, offer numerous health benefits; however, a comprehensive systematic summary of clinical evidence is currently lacking. The study was to assess the available evidence and provide an accurate estimate of the overall effects of
algae and its extracts supplementation on various health outcomes. The comprehensive searches in PubMed, Scopus, Embase, Web of Science, and the Cochrane Library until December 22, 2023 were implemented. The random-effects model was employed to pool the overall effect sizes (ESs) and the corresponding 95% confidence intervals (CIs) using Stata software. Moreover, detecting the methodological quality and evidence level of the eligible studies were employed by A Measurement Tool to Assess Systematic Review 2 (AMSTAR2) and the Grading of Recommendations Assessment Development and Evaluation. Ultimately, 25 articles covering 133 health outcomes were included in this umbrella review. The pooled results demonstrated that the
algae and its extracts could significantly decrease body weight (ES = -1.65; 95% CI: -1.97, -1.34; p < 0.001), body mass index (BMI) (ES = -0.42; 95% CI: -0.78, -0.07; p = 0.020), waist circumference (WC) (ES = -1.40; 95% CI: -1.40, -1.39; p < 0.001), triglyceride (TG) (ES = -1.38; 95% CI: -2.15, -0.62; p < 0.001), total cholesterol (TC) (ES: -1.40; 95% CI: -2.09, -0.72; p < 0.001), very low-density lipoprotein cholesterol (VLDL-C) (ES = -7.85; 95% CI: -8.55, -7.15; p < 0.001), fasting blood glucose (ES = -2.68; 95% CI: -4.57, -0.79; p = 0.005), glycated hemoglobin (HbA1c) (ES = -0.15; 95% CI: -0.24, -0.07; p < 0.001), systolic blood pressure (ES = -3.21; 95% CI: -5.25, -1.17; p = 0.002), diastolic blood pressure (ES = -3.84; 95% CI: -7.02, -0.65; p = 0.018), alanine transaminase (ES = -0.42; 95% CI: -0.70, -0.14; p = 0.003), and alkaline phosphatase (ES = -0.54; 95% CI: -0.99, -0.10; p = 0.017). Due to the limited number of studies, no benefit was displayed on markers of inflammation and oxidative stress. Considering the suboptimal quality of studies and the insufficient articles pertaining to certain outcomes, further well-designed research is imperative to substantiate the observed findings.