■该研究旨在分析0-17岁Omicron变种儿童SARS-CoV-2感染急性期的临床特征,总结急性COVID后4~12周的持续症状或新发临床表现。探讨学龄前儿童感染后疫苗接种状态与SARS-CoV-2中和抗体水平之间的关系。该综合研究系统描述了SARS-CoV-2感染儿童的临床特征,为儿童人群长期COVID的诊断和评估提供了依据。
■这项研究招募了转诊到儿童医院的儿童,首都儿科研究所,(北京,中国)从2023年1月10日至2023年3月31日。参与者被分类为婴儿和幼儿,幼儿园,学龄期,青少年群体。儿童或其法定监护人完成调查问卷,以提供以前的SARS-CoV-2感染史的信息,以及急性期的临床表现和感染后4至12周的长期症状。此外,我们从确诊有SARS-CoV-2感染史的儿童中收集血清样本,进行中和抗体的血清学检测.
■这项研究招募了总共2,001名0-17岁的儿童,他们以前通过核酸或抗原检测对SARS-CoV-2呈阳性。发热是1,902(95.1%)个体温在37.3至40.0°C范围内的主要临床表现。呼吸道症状被确定为继发性临床表现,咳嗽是777名(38.8%)儿童最常见的症状,其次是喉咙痛(22.1%),鼻塞(17.8%),流鼻涕(17.2%)。疲劳(21.6%),头痛(19.8%)和肌肉关节痛(13.5%)是儿童常见的全身症状.有SARS-CoV-2感染症状的儿童比例因年龄组而异。1,100名(55.0%)儿童在感染急性期后4至12周出现持续症状。故障集中(22.1%),咳嗽(22.1%),并且疲劳(12.1%)在延长的时间段内经常报告。少数儿童表现出胸闷的心血管症状,心动过速,胸痛报告为3.5%,2.5%,1.8%的儿童,分别。在472名3-5岁儿童中,208名儿童在感染前至少6个月接受了两剂SARS-CoV-2疫苗,3~5岁年龄组的长期COVID发生率与感染前疫苗接种情况无相关性(χ2=1.136,P=0.286)。
■在感染SARS-CoV-2Omicron变种的0-17岁儿童中,发热是急性期的主要临床表现,其次是呼吸道症状,系统性非特异性和消化性表现。特别是,呼吸和消化系统症状在6岁以上的儿童中更为常见。关于感染后4到12周的长期症状,最常见的演讲是集中困难,咳嗽,和疲劳。SARS-CoV-2的持续症状的发生率与疫苗接种状态没有显着相关性,这归因于6个月后疫苗诱导的体液免疫反应的功效下降。
UNASSIGNED: The study aims to analyze the clinical characteristics of acute phase of SARS-CoV-2 infection in children aged 0-17 years with the Omicron variant, and summarize the persistent
symptoms or new-onset clinical manifestations from 4 to 12 weeks after acute COVID. Explore the association between the vaccination status and SARS-CoV-2 neutralizing antibody levels post infection among preschool-aged children. The comprehensive study systematically describes the clinical characteristics of children infected with SARS-CoV-2, providing a foundation for diagnosis and evaluating long-term COVID in pediatric populations.
UNASSIGNED: The study enrolled children who were referred to the Children\'s Hospital, Capital Institute of Pediatrics, (Beijing,
China) from January 10, 2023 to March 31, 2023. Participants were classified as infant and toddlers, preschool, school-age, and adolescent groups. Children or their legal guardians completed survey questionnaires to provide information of previous SARS-CoV-2 infection history, as well as clinical presentation during the acute phase and long-term symptoms from 4 to 12 weeks following infection. Furthermore, serum samples were collected from children with confirmed history of SARS-CoV-2 infection for serological testing of neutralizing antibodies.
UNASSIGNED: The study recruited a total of 2,001 children aged 0-17 years who had previously tested positive for SARS-CoV-2 through nucleic acid or antigen testing. Fever emerged as the predominant clinical manifestation in 1,902 (95.1%) individuals with body temperature ranging from 37.3 to 40.0°C. Respiratory
symptoms were identified as secondary clinical manifestations, with cough being the most common symptom in 777 (38.8%) children, followed by sore throat (22.1%), nasal congestion (17.8%), and runnning nose (17.2%). Fatigue (21.6%), headache (19.8%) and muscle-joint pain (13.5%) were frequently reported systemic symptoms in children. The proportion of children with symptoms of SARS-CoV-2 infection varied across age groups. 1,100 (55.0%) children experienced persistent
symptoms from 4 to 12 weeks post the acute phase of infection. Trouble concentrating (22.1%), cough (22.1%), and fatigue (12.1%) were frequently reported across age groups in the extended period. A limited number of children exhibited cardiovascular
symptoms with chest tightness, tachycardia, and chest pain reported by 3.5%, 2.5%, and 1.8% of children, respectively. Among 472 children aged 3-5 years, 208 children had received two doses of SARS-CoV-2 vaccine at least 6 months prior to infection, and no association was found between the incidence of long-term COVID and pre-infection vaccination statuses among the 3-5 years age groups (χ2 = 1.136, P = 0.286).
UNASSIGNED: In children aged 0-17 years infected with SARS-CoV-2 Omicron variant, fever was the primary clinical manifestation in the acute phase, followed by respiratory symptoms, systemic non-specific and digestive presentations. In particular, respiratory and digestive system symptoms were more frequent in children aged above 6 years. Regarding the long-term symptoms from 4 to 12 weeks post-infection, the most common presentations were concentrating difficulty, cough, and fatigue. The incidence of persistent symptoms of SARS-CoV-2 did not exhibit a significant correlation with vaccination status, which was attributed to the waning efficacy of the vaccine-induced humoral immune response after 6 months.