■探讨早发性高度近视(eoHM)儿童的病因和脉络膜厚度(ChT)模式。
■在2019年1月至2021年12月之间,有60名eoHM儿童和20名健康对照者参加了这项研究。所有儿童均接受了全面的眼科检查,包括扫频源光学相干断层扫描。在中心凹区域以及1000μm和2500μm的鼻腔测量了ChT,temporal,上级,不如中央凹。
■总的来说,对60例eoHM儿童的120只眼进行了检查(平均等效球面,-8.88±3.05D;平均轴向长度,26.07±1.59mm)。单纯高度近视(SHM),家族性渗出性玻璃体视网膜病变(FEVR),和Stickler综合征(STL)是eoHM最常见的病因,并包括在进一步的ChT分析中。调整了SE的效果,多元回归分析显示,SHM患儿在N2500和I2500时的ChT最薄(p=0.039,p=0.013)。FEVR组在T2500时显示出更薄的ChT(p=0.023),而STL患者在所有位置均表现出稀薄的ChT。
■这项研究表明,SHM,STL和FEVR是最常见的病因,并显示出独特的ChT模式。不对称鼻ChT变薄是SHM的独特生物标志物,不对称时间ChT稀疏可能作为FEVR的生物标志物,对称扩散减薄在STL中更为常见。这些ChT模式可以提供方便,快,和非侵入性策略来区分eoHM的潜在病因。
UNASSIGNED: To explore the etiology and choroidal thickness (ChT) pattern in children with early-onset high myopia (eoHM).
UNASSIGNED: Sixty children with eoHM and 20 healthy controls were enrolled in this study between January 2019 and December 2021. All children underwent comprehensive ophthalmologic examinations including swept-source optical coherence tomography. ChT was measured in the subfoveal region and at 1000 μm and 2,500 μm nasal, temporal, superior, and inferior to the fovea.
UNASSIGNED: Overall, 120 eyes of 60 children with eoHM were examined (mean spherical equivalent, -8.88 ± 3.05 D; mean axial length, 26.07 ± 1.59 mm). Simple high myopia (SHM), familial exudative vitreoretinopathy (FEVR), and Stickler syndrome (STL) were the most frequent etiologies of eoHM and were included in further ChT analysis. Adjusted the effect of SE, multivariate regression analysis showed that children with SHM had thinnest ChT at N2500 and I2500 among the subgroups (p = 0.039, p = 0.013). FEVR group showed thinner ChT at T2500 (p = 0.023), while STL patients exhibited thin ChT at all locations.
UNASSIGNED: This study revealed that SHM, STL and FEVR was the most frequent etiology, and showed a distinctive pattern of ChT. Asymmetric nasal ChT thinning is a distinctive biomarker for SHM, asymmetric temporal ChT thinning might serve as a biomarker for FEVR, and symmetric diffuse thinning is more common in STL. These ChT patterns may provide a convenient, fast, and noninvasive strategy to differentiate the potential etiology of eoHM.