■肺动脉高压(PH)是一种危及生命的疾病,尤其是在儿科人群中。儿科PH的症状是非特异性的。儿科PH的准确检测有助于早期治疗和降低死亡率。因此,我们评估了脑钠肽(BNP)和N末端脑钠肽(NT-proBNP)在儿科人群中诊断PH的总体表现.
■PubMed,WebofScience,CochraneLibrary和Embase数据库自各自成立以来一直进行筛选,直到2023年8月。双变量随机模型和分层汇总接收器工作特征模型一起用于评估和总结BNP和NT-proBNP诊断儿科PH的总体性能。
■评估了18项使用BNP/NT-proBNP的研究,包括1127个样本。汇集的敏感性,特异性,正似然比(PLR),负似然比(NLR),BNP/NT-proBNP的诊断比值比(DOR)和曲线下面积(AUROC)分别为0.81,0.87,6.33,0.21,29.50和0.91,提示BNP/NT-proBNP在儿科人群中检测PH具有良好的诊断性能.对于BNP,汇集的敏感性,特异性,PLR,NLR,DOR和AUROC分别为0.83、0.89、7.76、0.19、40.90和0.93,表明BNP对小儿PH患者的诊断准确性较好。对于NT-proBNP,汇集的敏感性,特异性,PLR,NLR,DOR和AUROC分别为0.81、0.86、5.59、0.22、24.96和0.90,表明NT-proBNP可以为检测儿科PH提供良好的价值。
BNP和NT-proBNP都是区分儿科PH患者和非PH患者的良好标志物。
小儿PH的准确检测有助于早期治疗和降低死亡率。这项研究表明,BNP和NT-proBNP都是检测儿科PH的良好标志物。在临床实践中,我们推荐BNP和NT-proBNP是诊断儿科PH的辅助生物标志物.
UNASSIGNED: Pulmonary hypertension (PH) is a life-threatening disease, especially in paediatric population. Symptoms of paediatric PH are non-specific. Accurate detection of paediatric PH is helpful for early treatment and mortality reduction. Therefore, we assessed the overall performance of brain natriuretic peptide (BNP) and N-terminal brain natriuretic peptide (NT-proBNP) for diagnosing PH in paediatric population.
UNASSIGNED: PubMed, Web of Science, Cochrane Library and Embase databases were screened since their respective inceptions until August 2023. A bivariate random model and a hierarchical summary receiver operating characteristic model were used together to evaluate and summarize the overall performance of BNP and NT-proBNP for diagnosing paediatric PH.
UNASSIGNED: Eighteen studies using BNP/NT-proBNP were assessed, comprising 1127 samples. The pooled sensitivity,
specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and area under the curve (AUROC) of BNP/NT-proBNP were separately as 0.81, 0.87, 6.33, 0.21, 29.50 and 0.91, suggesting a good diagnostic performance of BNP/NT-proBNP for detecting PH in paediatric population. For BNP, the pooled sensitivity,
specificity, PLR, NLR, DOR and AUROC were 0.83, 0.89, 7.76, 0.19, 40.90 and 0.93, indicating the diagnostic accuracy of BNP for paediatric PH patients was good. For NT-proBNP, the pooled sensitivity,
specificity, PLR, NLR, DOR and AUROC were 0.81, 0.86, 5.59, 0.22, 24.96 and 0.90, showing that NT-proBNP could provide a good value for detecting paediatric PH.
UNASSIGNED: Both BNP and NT-proBNP are good markers for differentiating paediatric PH patients from non-PH individuals.
Accurate detection of paediatric PH is helpful for early treatment and mortality reduction. This study shows that both BNP and NT-proBNP are good markers for detecting paediatric PH. In clinical practice, we recommend that BNP and NT-proBNP are auxiliary biomarkers in diagnosing paediatric PH.