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Abstract：
OBJECTIVE: To assess the diagnostic value of C-reactive protein (CRP) and procalcitonin (PCT) for anastomotic leakage (AL) following colorectal surgery.
METHODS: We retrospectively analyzed data for patients who underwent colorectal surgery at our hospital between November 2019 and December 2023. CRP and PCT were measured postoperatively to compare patients with/without AL, and changes were compared between low- and high-risk groups. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic accuracy of CRP and PCT to identify AL in high-risk patients.
RESULTS: Mean CRP was 142.53 mg/L and 189.57 mg/L in the low- and high-risk groups, respectively, on postoperative day (POD)3. On POD2, mean PCT was 2.75 ng/mL and 8.16 ng/mL in low- and high-risk patients, respectively; values on POD3 were 3.53 ng/mL and 14.86 ng/mL, respectively. The areas under the curve (AUC) for CRP and PCT on POD3 were 0.71 and 0.78, respectively (CRP cut-off: 235.64 mg/L; sensitivity: 96%; specificity: 89.42% vs PCT cut-off: 3.94 ng/mL; sensitivity: 86%; specificity: 93.56%; AUC: 0.78). The AUC, sensitivity, and specificity for the combined diagnostic ability of CRP and PCT on POD3 were 0.92, 90%, and 100%, respectively (cut-off: 0.44).
CONCLUSIONS: Combining PCT and CRP on POD3 enhances the diagnostic accuracy for AL.
METHODS: We retrospectively analyzed data for patients who underwent colorectal surgery at our hospital between November 2019 and December 2023. CRP and PCT were measured postoperatively to compare patients with/without AL, and changes were compared between low- and high-risk groups. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic accuracy of CRP and PCT to identify AL in high-risk patients.
RESULTS: Mean CRP was 142.53 mg/L and 189.57 mg/L in the low- and high-risk groups, respectively, on postoperative day (POD)3. On POD2, mean PCT was 2.75 ng/mL and 8.16 ng/mL in low- and high-risk patients, respectively; values on POD3 were 3.53 ng/mL and 14.86 ng/mL, respectively. The areas under the curve (AUC) for CRP and PCT on POD3 were 0.71 and 0.78, respectively (CRP cut-off: 235.64 mg/L; sensitivity: 96%; specificity: 89.42% vs PCT cut-off: 3.94 ng/mL; sensitivity: 86%; specificity: 93.56%; AUC: 0.78). The AUC, sensitivity, and specificity for the combined diagnostic ability of CRP and PCT on POD3 were 0.92, 90%, and 100%, respectively (cut-off: 0.44).
CONCLUSIONS: Combining PCT and CRP on POD3 enhances the diagnostic accuracy for AL.
摘要：
目的：评价C-反应蛋白(CRP)和降钙素原(PCT)对结直肠术后吻合口瘘(AL)的诊断价值。
方法：我们回顾性分析了2019年11月至2023年12月在我院接受结直肠手术的患者的数据。术后测定CRP和PCT,比较有无AL患者,并比较了低危组和高危组之间的变化。采用受试者工作特征（ROC）曲线分析评估CRP和PCT对高危患者AL的诊断准确性。
结果：低危和高危人群的平均CRP分别为142.53mg/L和189.57mg/L，分别,术后当天（POD）3。在POD2上，低风险和高风险患者的平均PCT为2.75ng/mL和8.16ng/mL，POD3的值分别为3.53ng/mL和14.86ng/mL，分别。POD3上CRP和PCT的曲线下面积（AUC）分别为0.71和0.78（CRP截止值：235.64mg/L；灵敏度：96％；特异性：89.42％，PCT截止值：3.94ng/mL；灵敏度：86％；特异性：93.56％；AUC：0.78）。AUC,灵敏度,CRP和PCT联合诊断POD3的特异性分别为0.92、90%,100%,分别（截止：0.44）。
结论：将PCT和CRP联合应用于POD3可提高AL的诊断准确性。
方法：我们回顾性分析了2019年11月至2023年12月在我院接受结直肠手术的患者的数据。术后测定CRP和PCT,比较有无AL患者,并比较了低危组和高危组之间的变化。采用受试者工作特征（ROC）曲线分析评估CRP和PCT对高危患者AL的诊断准确性。
结果：低危和高危人群的平均CRP分别为142.53mg/L和189.57mg/L，分别,术后当天（POD）3。在POD2上，低风险和高风险患者的平均PCT为2.75ng/mL和8.16ng/mL，POD3的值分别为3.53ng/mL和14.86ng/mL，分别。POD3上CRP和PCT的曲线下面积（AUC）分别为0.71和0.78（CRP截止值：235.64mg/L；灵敏度：96％；特异性：89.42％，PCT截止值：3.94ng/mL；灵敏度：86％；特异性：93.56％；AUC：0.78）。AUC,灵敏度,CRP和PCT联合诊断POD3的特异性分别为0.92、90%,100%,分别（截止：0.44）。
结论：将PCT和CRP联合应用于POD3可提高AL的诊断准确性。
