Severe mental disorders

严重精神障碍
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  • 文章类型: Journal Article
    评估患有严重精神疾病(SMI)的个人的康复状况需要对多模态数据进行全面分析,包括非结构化文本记录和结构化诊断数据。然而,有效评估康复状况的进展仍然有限。我们的研究开发了一种深度学习模型,通过后期融合策略将变形金刚(BERT)和TabNet的双向编码器表示集成,以增强康复预测。包括转诊风险,危险的行为,自我意识,和药物依从性,SMI患者。BERT处理非结构化文本数据,如医生的笔记,而TabNet管理结构化的诊断信息。该模型的可解释性功能可帮助医疗保健专业人员理解模型的预测性决策,改善患者护理。我们的模型对所有四个任务都表现出出色的预测性能,精度超过0.78,曲线下面积为0.70。此外,一系列测试证明了模型的鲁棒性,公平,和可解释性。本研究将多模态和多任务学习策略结合到一个模型中,并将其应用于康复评估任务,提供了一种有前途的新工具,可以与临床工作流程无缝集成,以支持提供优化的患者护理。
    Evaluating the rehabilitation status of individuals with serious mental illnesses (SMI) necessitates a comprehensive analysis of multimodal data, including unstructured text records and structured diagnostic data. However, progress in the effective assessment of rehabilitation status remains limited. Our study develops a deep learning model integrating Bidirectional Encoder Representations from Transformers (BERT) and TabNet through a late fusion strategy to enhance rehabilitation prediction, including referral risk, dangerous behaviors, self-awareness, and medication adherence, in patients with SMI. BERT processes unstructured textual data, such as doctor\'s notes, whereas TabNet manages structured diagnostic information. The model\'s interpretability function serves to assist healthcare professionals in understanding the model\'s predictive decisions, improving patient care. Our model exhibited excellent predictive performance for all four tasks, with an accuracy exceeding 0.78 and an area under the curve of 0.70. In addition, a series of tests proved the model\'s robustness, fairness, and interpretability. This study combines multimodal and multitask learning strategies into a model and applies it to rehabilitation assessment tasks, offering a promising new tool that can be seamlessly integrated with the clinical workflow to support the provision of optimized patient care.
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  • 文章类型: Journal Article
    背景:精神障碍患者的堕胎行为对女性健康构成主要障碍。然而,很少有研究报道中国严重精神障碍妇女流产的患病率和相关因素。因此,本研究旨在调查农村社区女性患者的流产率,并确定潜在的健康风险。
    方法:这是一项针对山东省农村276名18岁及以上严重精神障碍妇女的横断面研究。中国。怀孕史,采用问卷调查法调查妇女的流产史和社会人口学特征。采用Logistic回归分析不同流产行为的相关因素。
    结果:研究显示82.61%(228/276)的患者有妊娠史。在有妊娠史的患者中,43.42%(99/228)报告说至少有一次流产,15.79%(36/228)有一个以上。在另一边,31.58%(72/228)的患者发生自然流产,12.72%(29/228)发生人工流产。首次妊娠年龄(aOR0.80,95%CI0.70-0.90)和最后妊娠年龄(aOR1.17,95%CI1.07-1.27)均与流产有关。焦虑与自发性(aOR1.08,95%CI1.02-1.15)和重复流产(aOR1.10,95%CI1.01-1.19)有关。此外,宗教(AOR10.47,95%CI2.81-39.01),儿童数量≥2(aOR0.18,95%CI0.04-0.77),家庭功能(aOR1.31,95%CI1.06-1.63)与人工流产有关。
    结论:农村地区患有严重精神障碍的妇女流产率明显高于一般女性,特别是自然流产。妊娠患者的孕龄和焦虑情绪值得关注,并采取预防措施,以避免流产的结局。
    BACKGROUND: Abortion behaviors among individuals with mental disorders presented major obstacles to women\'s health. However, few studies reported the prevalence and associated factors of abortion among women with severe mental disorders in China. Consequently, this study aims to investigate the prevalence of abortion among female patients in rural communities and identify potential health risks.
    METHODS: This was a cross-sectional study of 276 women aged 18 years and older with severe mental disorders in rural areas of Shandong Province, China. The pregnancy history, abortion history and socio-demographic characteristics of women were investigated by questionnaire. Logistic regression analysis was employed to examine the associated factors for different abortion behaviors.
    RESULTS: The study showed that 82.61 % (228/276) of patients had a pregnancy history. Among the patients with a pregnancy history, 43.42 % (99/228) reported having had at least one abortion, and 15.79 % (36/228) had more than one. In the other side, 31.58 % (72/228) of them experienced spontaneous abortion, while 12.72 % (29/228) experienced induced abortion. Age at first gestation (aOR 0.80, 95 % CI 0.70-0.90) and age at last gestation (aOR 1.17, 95 % CI 1.07-1.27) were both associated with abortion. Anxiety was related to spontaneous (aOR 1.08, 95 % CI 1.02-1.15) and repeat abortions (aOR 1.10, 95 % CI 1.01-1.19). In addition, religion (aOR 10.47, 95 % CI 2.81-39.01), number of children≥2 (aOR 0.18, 95 % CI 0.04-0.77), and family functioning (aOR 1.31, 95 % CI 1.06-1.63) were associated with induced abortion.
    CONCLUSIONS: Women with severe mental disorders in rural regions have notably higher rates of abortion compared to the general female population, particularly for spontaneous abortions. Gestational age and anxiety of pregnant patients deserve attention and preventive measures to avoid the outcomes of abortion.
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  • 文章类型: Journal Article
    一些研究探讨了教育水平与药物依从性之间的关系,以及教育水平与认知功能的关系。然而,很少有关于教育水平之间关系的研究,认知功能,和药物依从性。本研究旨在探讨认知功能在精神分裂症患者受教育程度与服药依从性之间是否具有中介作用。
    本研究共纳入329名参与者。使用精神分裂症的认知简短评估来评估认知功能,使用药物依从性问卷和药物依从性。通过多变量线性回归分析检验了影响服药依从性的临床因素与认知功能之间的关系。使用带有PROCESS宏的自举方法测试了药物依从性的中介作用。
    家族史,精神分裂症患者的自知力和执行功能与药物依从性相关,执行功能在教育水平和药物依从性之间具有中介作用。
    采用促进认知发展以及积极干预执行功能的特定教育计划可能有助于改善精神分裂症患者的服药依从性。
    UNASSIGNED: Several studies have explored the relationship between level of education and medication adherence, as well as the relationship between level of education and cognitive function. However, there have been few studies on the relationships between level of education, cognitive function, and medication adherence. This study aimed to explore whether cognitive function has a mediating effect between level of education and medication adherence in patients with schizophrenia.
    UNASSIGNED: A total of 329 participants were included in this study. Cognitive function was assessed using the Brief Assessment of Cognition in Schizophrenia, and medication adherence using the Medication Adherence Questionnaire. The relationships between the clinical factors and cognitive function that contributed to medication adherence were tested through multivariable linear regression analysis. The mediating effect of medication adherence was tested using the bootstrapping approach with the PROCESS macro.
    UNASSIGNED: Family history, insight and executive function were associated with medication adherence in individuals with schizophrenia, and executive function had a mediating effect between level of education and medication adherence.
    UNASSIGNED: Adopting specific education programs that promote cognitive development as well as actively intervening in executive function might be conducive to improve medication adherence in patients with schizophrenia.
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  • 文章类型: Journal Article
    目的:调查登记病例相对于大小的比例,分布特征,用药状态,福州市严重精神障碍(SMD)患者的治疗现状。比较城市与非城市地区患者的用药状况和管理状况,为改善SMD护理提供科学依据。control,和初级卫生保健机构的治疗。
    方法:数据(病例类型,人口统计数据,分布数据,用药状态,和管理地位,等。)在12个地区诊断为SMD的患者中,郡,2017年10月至2018年9月,福州市城区和非城区地州收集。三种分布(人口,当地,和地区/县)用于描述注册病例相对于已诊断的SMD的大小和临床特征的比例。使用卡方(χ2)检验比较城市和非城市地区的严重程度。
    结果:福州市共有登记的SMD患者30,362例,其中精神分裂症患者占最多(26,204例,占86.31%),和偏执性精神病的病例数最少(47,0.15%)。此外,大约一半的SMD患者年龄为18~44岁(45.38%).近三分之一的患者是农民(30.23%),有小学或较低的教育水平(54.17%),很穷,大多数人处于贫困线以下(55.35%)。诊断的SMD相对于大小的比例在闽清县最高(0.53%),在马尾区最低(0.38%)。共有22,989人(75.72%)在服用药物,只有17509(57.67%)定期服药。此外,城市地区服用药物和定期服用药物的病例百分比高于非城市地区(P<0.05)。共有3065名患者注册管理(10.09%)。城市地区SMD病例的管理比例高于非城市地区(P<0.05)。
    结论:精神分裂症是福州市重性精神障碍综合护理和控制的重点疾病。严重精神障碍的管理应侧重于低教育背景的贫困群体。城市地区的药物使用和管理比非城市地区好,因此,应该加强非城市地区的管理。福州市严重精神障碍患者的用药管理和病例管理有待进一步改进。
    To investigate the proportion of registered cases relative to size, distribution characteristics, medication status, and management status of patients diagnosed with severe mental disorders (SMD) in Fuzhou. The medication status and management status were compared between patients in urban and non-urban areas to provide scientific evidence for improving SMD care, control, and treatment in primary health care institutions.
    Data (case types, demographic data, distribution data, medication status, and management status, etc.) of patients diagnosed with SMD in 12 districts, counties, and prefectures in the urban and non-urban areas of Fuzhou City were collected from October 2017 to September 2018. Three distributions (population, local, and districts/counties) were used to describe the proportion of registered cases relative to size and clinical characteristics of diagnosed SMD. Chi squared (χ2) test was used to compare the severity in urban and non-urban areas.
    A total of 30,362 registered SMD patients were identified in Fuzhou City of which schizophrenia accounted for the highest number of cases (26,204, 86.31%), and paranoid psychosis had the least number of cases (47, 0.15%). Moreover, approximately half of SMD patients were 18 to 44 years old (45.38%). Close to one third of patients were farmers (30.23%), had a primary school or lower education level (54.17%), were poor, with most below the poverty line (55.35%). The proportion of diagnosed SMD relative to size was highest in Minqing County (0.53%) and lowest in Mawei District (0.38%). A total of 22,989 (75.72%) of the patients were taking medications, and only 17,509 (57.67%) were taking medications regularly. Moreover, the percentage of cases taking medications and those taking medications regularly were higher in urban areas than in non-urban areas (P<0.05). A total of 3065 patients were registered for management (10.09%). The managed proportion of SMD cases was higher in the urban areas than in the non-urban areas (P < 0.05).
    Schizophrenia is a key disease for comprehensive care and control of severe mental disorders in Fuzhou. The management of severe mental disorders should focus on poor groups with low educational backgrounds. Drug usage and management are better in urban areas than in non-urban areas, and thus management should be enhanced in non-urban areas. The medication management and case management of patients with severe mental disorders in Fuzhou need further improvements.
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  • 文章类型: Journal Article
    了解可归因于严重精神障碍的区域负担的规模和时空分布具有重要的必要性和高度的政策相关性。该研究旨在通过评估失去的寿命来解决严重精神障碍的负担,多年生活在残疾中,广东省的残疾调整寿命年(DALYs),中国。
    我们根据广东省卫生健康委员会建立的多中心数据库进行了纵向研究,共涉及广东省21个地州和四个经济区。共收集了2010-2020年来自严重精神障碍患者的520,731份医疗记录。通过综合患病率估计,通过综合评估框架分析数据,流行病学调整以及合并症评估,以开发DALY的内部一致估计。2010-2020年的DALY变化按人口增长和老龄化分解,并按社会人口指数(SDI)进一步分组。根据2010-2020年加权中值年化变化率,预计到2030年的DALY。
    在2010-2020年,严重精神障碍的平均DALYs达到798,474(95%不确定区间[UI]:536,280-1,270,465)人年(男性为52.2%,女性为47.8%)。严重的精神障碍导致了大量的疾病负担,尤其是在广州,深圳,和佛山市。精神分裂症和患有精神障碍的智力低下是导致严重精神障碍的负担的两个主要来源。人口增长和老龄化可能是造成严重精神障碍负担增加的原因。SDI较高的经济区域负担更大,但DALY的年化变化率较低。预计未来十年,严重精神障碍的总体负担将略有上升。
    调查结果敦促优先关注公共心理健康的举措,预防策略,卫生资源再分配,以及当局的积极参与,以有效满足预期的需求。
    To understand the magnitude and spatial-temporal distribution of the regional burden attributable to severe mental disorders is of great essential and high policy relevance. The study aimed to address the burden of severe mental disorders by evaluating the years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) in Guangdong, China.
    We undertook a longitudinal study based on a multicenter database established by the Health Commission of Guangdong, involving a total of 21 prefectures and four economic regions in the Guangdong province. A total of 520,731 medical records from patients with severe mental disorders were collected for 2010-2020. Data were analyzed via an integrated evaluation framework by synthesizing prevalence estimates, epidemiological adjustment as well as comorbidity assessment to develop internally consistent estimates of DALY. DALY changes during 2010-2020 were decomposed by population growth and aging and further grouped by Socio-demographic Index (SDI). DALYs were projected to 2030 by the weighted median annualized rate of change in 2010-2020.
    In 2010-2020, the average DALYs for severe mental disorders reached 798,474 (95% uncertainty interval [UI]: 536,280-1,270,465) person-years (52.2% for males, and 47.8% for females). Severe mental disorders led to a great amount of disease burden, especially in Guangzhou, Shenzhen, and Foshan cities. Schizophrenia and mental retardation with mental disorders were the two leading sources of the burden ascribed to severe mental disorders. Population growth and aging could be accountable for the increasing burden of severe mental disorders. Economic regions with higher SDI carried a greater burden but had lower annualized rates of change in DALYs. The overall burden of severe mental disorders is projected to rise modestly over the next decade.
    The findings urge prioritization of initiatives focused on public mental health, prevention strategies, health resources reallocation, and active involvement of authorities to effectively address the anticipated needs.
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  • 文章类型: Journal Article
    严重的精神障碍由于其对生活质量和功能的严重后果,已成为研究兴趣日益增加的话题。在接下来的页面中,认为北京市严重精神障碍患者的自我护理能力及其影响因素,根据2019年的问卷调查。
    使用比例分层抽样来选择代表性患者作为样本。从严重精神障碍管理信息系统和问卷获得的人口统计学特征。自理能力由自制量表测量。描述性统计,t检验,并采用多元线性回归分析数据。
    我们调查了662人,发现生活自理能力不足在严重精神障碍患者中很常见。自理能力与受教育程度呈正相关,监护人单独照顾,与年龄负相关,病程和躯体疾病(P<0.05)。从维度的角度来看,日常基本活动与受教育程度呈正相关,与躯体疾病呈负相关(P<0.05);家务劳动能力与性别呈正相关,受教育程度和药物依从性,与经济来源和躯体疾病呈负相关(P<0.05);社会功能与受教育程度呈正相关,监护人独自照顾和药物依从性,与年龄负相关,收入来源,病程和躯体疾病(P<0.05)。
    严重精神障碍患者的自我护理能力受多种因素影响,包括患者特征和社会因素。因此,需要有针对性的干预措施来帮助患者恢复自我护理能力,这需要政府和全社会的共同努力。
    Severe Mental Disorders have become a topic of increasing interest in research due to their serious consequences for the quality of life and functioning. In the pages that follow, it will be argued that the self-care ability and its influencing factors among patients with severe mental disorders in Beijing, according to the questionnaire survey in 2019.
    Proportionate stratified sampling was used to select representative patients as samples. The demographic characteristics of were obtained from the Management Information System for Severe Mental Disorders and the questionnaires. The self-care ability was measured by self-made scales. Descriptive statistics, t-test, and multiple linear regression were used to analyze the data.
    We surveyed 662 people and found that the deficiency of self-care ability is common in patients with severe mental disorders. Self-care ability was positively correlated with educated levels and guardian takes care of alone, and negatively correlated with age, course of disease and physical disease (P < 0.05). From a dimensional perspective, the daily basic activity was positively correlated with educated levels and negatively correlated with physical disease (P < 0.05); the housework ability was positively correlated with gender, educated levels and medication adherence, and negatively correlated with source of income and physical disease (P < 0.05); the social function was positively correlated with educated levels, guardian takes care of alone and medication adherence, and negatively correlated with age, source of income, course of disease and physical disease (P < 0.05).
    The self-care ability of patients with severe mental disorders is affected by many factors, including patient characteristics and social factors. Therefore, targeted interventions are needed to help patients restore their self-care ability, which requires the joint efforts of the government and the whole society.
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  • 文章类型: Journal Article
    背景:COVID-19在短时间内传播到全球,影响了人们的生活,特别是患有严重精神障碍的患者。抗精神病药物依从性差通常与复发风险增加有关。本研究调查了COVID-19暴发期间低收入家庭严重精神障碍患者的用药依从性状况及其影响因素。
    方法:选择中国中部河南省低收入家庭的严重精神障碍患者,采用多阶段分层随机抽样方法。训练有素的面试官和精神科医生通过面对面访谈或视频访谈收集了患者的问卷答复。采用Logistic回归模型分析影响服药依从性的因素。
    结果:在2020年3月10日至2020年3月31日之间共收集了24,763份有效问卷。COVID-19暴发期间低收入家庭严重精神障碍患者的常规用药率为51.46%。发现12个因素影响被调查个体的药物依从性。定期用药的积极因素是年龄较小,患者及其监护人的教育水平较高,更高的医疗支出,更高水平的自理能力,有护理和监督补贴,有残疾证明和个人护理,等。
    结论:COVID-19疫情影响低收入家庭严重精神障碍患者的用药依从性。影响因素复杂多样,包括心理影响,交通影响,和经济,等。政府应该在社会救助项目上付出更多的努力,并灵活应对像COVID-19这样的突发公共卫生事件中的困难。
    BACKGROUND: The COVID-19 has spread across the globe in a short time and affected people\'s life, especially patients with severe mental disorders. Poor adherence to antipsychotics was usually associated with an increasing risk of relapse. This study investigated medication adherence status among patients with severe mental disorders in low-income families during COVID-19 outbreak and the influencing factors.
    METHODS: To select patients with severe mental disorders in low-income families in central China\'s Henan Province, we used multi-stage stratified random sampling method. Trained interviewers and psychiatrists collected questionnaire responses from the patients through face-to-face interviews or video interviews. Logistic regression models were used to examine factors that influence the status of medication adherence.
    RESULTS: A total of 24,763 valid questionnaires were collected between March 10, 2020, and March 31, 2020. The regular medication rate of patients with severe mental disorders in low-income families during the COVID-19 outbreak was 51.46%. Twelve factors were found to influence medication adherence of investigated individuals. Positive factors for regular medication were younger age, higher education level of patients and their guardians, higher medical expenditure, higher level of self-care ability, having subsidies for care and supervision, having disability certificate and personal care, etc.
    CONCLUSIONS: The COVID-19 outbreak affected the medication adherence among patients with severe mental disorders in low-income families. The influencing factors are complicated and diverse, including psychological effects, traffic impact, and economy, etc. The government should pay more efforts on social assistance programs and flexibly deal with difficulties during public health emergencies like the COVID-19.
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  • 文章类型: Journal Article
    Medication adherence is a common issue influenced by various factors among patients with severe mental disorders worldwide. However, most literature to date has been primarily quantitative and has focused on medication adherence issue from the perspective of patients or their caregivers. Moreover, research focused on medication adherence issue in China is scarce. Present study aims to explore the influential factors of medication adherence among patients with severe mental disorders form the perspective of mental health professionals in Hunan Province, China.
    A qualitative study was performed in Hunan Province, China with 31 mental health professionals recruited from October to November 2017. And semi-structured interviews or focus group interviews were conducted along with audio recordings of all interviews. Interview transcripts were then coded and analyzed in Nvivo software with standard qualitative approaches.
    Three major themes influencing medication adherence among patients with severe mental disorders were identified as: (1) attitudes towards mental disorder/treatment; (2) inadequate aftercare; (3) resource shortages.
    This qualitative study identified the factors influencing medication adherence among patients with severe mental disorders in China. As a locally driven research study, it provides practical advice on medication adherence promotion for mental health workers and suggests culturally tailored models that improve the management of patients with severe mental disorders in order to reduce economic burden on individual and societal level.
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  • 文章类型: Journal Article
    2016年,宝安区政府,深圳,中国为其管辖范围内所有非登记的患有严重精神障碍(SMD)的永久居民启动了免费药物治疗计划,努力减少间歇性药物或非药物引起的复发。自成立以来,尚未对该计划的参与进行分析。本研究旨在评估2016年至2020年非SMD注册永久居民参与该计划的情况,并探讨其影响因素。
    这是一项对宝安区3760名非登记永久性SMD居民的回顾性横断面研究,深圳,中国(答复率:78.64%)。数据来自两个来源:2020年的深圳市精神病信息系统和2016年至2020年的免费用药计划管理档案。我们采用描述性统计数据来分析非注册永久患者中免费药物计划的参与率。采用Logistic回归分析探讨影响患者参与项目的因素。
    非注册永久病人的免费用药计划参与率呈上升趋势,从2016年的28.83%上升到2020年的58.32%。在以下患者亚组中记录了较高的参与率:年龄在30至39岁之间的患者(63.11%),高中/中专学生(62.33%),来自农村地区的人(61.62%),生活在贫困中的人(67.79%),患有分裂情感障碍的人(72.26%),SMD少于5年(59.89%),和有精神病家族史的人(71.23%)。物流回归分析表明,年龄,患者-监护人关系,居住地,财务状况,疾病的类型,病程和家族史是影响患者决定参加免费用药计划的主要因素。
    免费药物治疗计划的参与率稳步提高,表明该计划已逐渐被SMD非注册永久居民接受和认可。然而,近一半的患者尚未加入该计划。为了进一步提高参与率,应该特别注意经济上有保障的病人,20岁以下,没有监护人,智力残疾或患有SMD超过5年。
    In 2016, the government of Bao\'an District, Shenzhen, China launched a free medication program for all non-registered permanent residents with severe mental disorders (SMD) within its jurisdiction, in efforts to reduce the relapse caused by intermittent medication or non-medication. Participation in the program has not been analyzed since its inauguration. This study aimed to evaluate the participation of non-registered permanent residents with SMD in the program from 2016 to 2020 and to explore its influencing factors.
    This is a retrospective cross-sectional study of 3760 non-registered permanent residents with SMD in Bao\'an District, Shenzhen, China (response rate: 78.64%). Data have been obtained from two sources: the Shenzhen Information System for Psychosis in 2020 and the free medication program\'s management files from 2016 to 2020. We employ descriptive statistics to analyze the participation rate of the free medication program among non-registered permanent patients. Logistic regression analysis is used to explore the factors affecting the patients\' participation in the program.
    The participation rate of the free medication program among non-registered permanent patients has shown an upward trend, rising from 28.83% in 2016 to 58.32% in 2020. High participation rates have been registered among the following patient subgroups: those aged between 30 and 39 (63.11%), those with high school/technical secondary school (62.33%), those from rural areas (61.62%), those living in poverty (67.79%), those suffering schizoaffective disorder (72.26%), those having SMD for less than 5 years (59.89%), and those with family history of mental illness (71.23%).Logistics regression analysis shows that age, patient-guardian relationship, place of residence, financial condition, types of disease, duration of illness and family history are the main factors affecting the patients\' decision to participate in the free medication program.
    The steadily increasing participation rate of the free medication program indicates that the program has been gradually accepted and recognized by non-registered permanent residents with SMD. However, nearly half of the patients have yet to join the program. To further raise the participation rate, special attention should be given to patients who are financially secure, aged below 20, without guardians, intellectually disabled or suffering SMD for over 5 years.
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