背景:中药(TCM)正变得越来越流行,相关的不良事件经常被忽略或低估。
目的:本系统综述旨在评估中医肝损伤(TCM-ILI)的临床特征和结局,并评估中医-ILI在所有药物性肝损伤(DILI)中的比例。
方法:中国国家知识基础设施,万方,VIP,PubMed,搜索了Embase数据库。人口统计,临床,和生存数据被提取和汇集。计算与较差结果相关的因素。对于比例荟萃分析,数据采用随机效应模型进行汇总.
结果:总体而言,检索到21,027篇文章,最终包括625个。女性和老年患者占主导地位。肝移植的比例为2.18%(7/321)。死亡率为4.67%(15/321)。男性,高天冬氨酸转氨酶和直接胆红素,和低白蛋白与TCM-ILI患者死亡/肝移植风险增加显著相关.TCM-ILI在所有DILI中所占比例为25.71%。比例随年份逐渐增加。
结论:我们的工作总结了当前有关临床表现的知识,病程,和中医-ILI的预后。中医可以导致肝毒性,甚至死亡或需要挽救生命的肝移植。应严格建立政府对中药产品的监管。
BACKGROUND: Traditional Chinese medicine (TCM) is becoming increasingly popular and related adverse events are often ignored or underestimated.
OBJECTIVE: This systematic review aimed to evaluate the clinical characteristics and outcomes of TCM-induced liver injury (TCM-ILI) and to estimate the proportion of TCM-ILI in all drug-induced liver injuries (DILI).
METHODS: China National Knowledge Infrastructure, Wanfang, VIP, PubMed, and Embase databases were searched. Demographic, clinical, and survival data were extracted and pooled. Factors associated with worse outcomes were calculated. For the proportion meta-analyses, the data were pooled by using a random-effects model.
RESULTS: Overall, 21,027 articles were retrieved, of which 625 were finally included. There was a predominance of female and older patients. The proportion of liver transplantation was 2.18% (7/321). The mortality was 4.67% (15/321). Male, higher aspartate aminotransferase and direct bilirubin, and lower albumin were significantly associated with an increased risk of death/liver transplantation in TCM-ILI patients. The proportion of TCM-ILI in all DILI was 25.71%. The proportion was gradually increased with year.
CONCLUSIONS: Our work summarises current knowledge regarding clinical presentation, disease course, and prognosis of TCM-ILI. TCM can result in hepatotoxicity, even death or necessitate life-saving liver transplantation. Governmental regulation of TCM products should be strictly established.