背景:睾丸癌(TC)是年轻成年男性中最常见的恶性肿瘤,自20世纪中叶以来,在许多国家,睾丸癌的发病率一直在增加。由于疾病表现和肿瘤进展模式通常在不同种族群体中是异质的,最近的TC趋势可能存在重要的种族差异。
方法:在本研究中,监视,流行病学,对1973年至2015年诊断的TC患者的最终结果(SEER)数据进行了分析,包括以下种族/族裔群体:非西班牙裔白人(NHW),西班牙裔白人(HW),黑人,亚洲人和太平洋岛民(API)。患者特征,年龄调整后的发病率,和生存率进行了不同种族的比较。采用多变量Cox模型对TC患者的生存数据进行分析,为了评估几个相关因素的种族差异,包括婚姻状况,年龄组,组织学类型,治疗,舞台,和肿瘤的位置。
结果:NHW的发病率最高,其次是黑人,HWs,和API。种族之间有显著的生存差异,NHW的存活率最高,黑人的存活率最低。
结论:对SEER数据的分析表明,美国TC患者在患者特征方面存在种族差异,发病率,和生存。结果对有兴趣减少TC发病率和死亡率的利益相关者有用。
BACKGROUND: Testicular cancer (TC) is the most common malignancy in young adult men, and in many countries the incidence rates of testicular cancer have been increasing since the middle of the twentieth century. Since disease presentation and tumor progression patterns are often heterogeneous across racial groups, there may be important racial differences in recent TC trends.
METHODS: In this study, Surveillance, Epidemiology, and End Results (SEER) data on TC patients diagnosed between 1973 and 2015 were analyzed, including the following racial/ethnic groups: non-Hispanic whites (NHW), Hispanic whites (HW), blacks, and Asians and Pacific Islanders (API). Patient characteristics, age-adjusted incidence rates, and survival were compared across racial groups. A multivariate Cox model was used to analyze the survival data of TC patients, in order to evaluate racial differences across several relevant factors, including marital status, age group, histologic type, treatment, stage, and tumor location.
RESULTS: NHWs had the highest incidence rates, followed by blacks, HWs, and APIs. There were significant survival differences among the racial groups, with NHWs having the highest survival rates and blacks having the lowest.
CONCLUSIONS: An analysis of SEER data showed that racial differences existed among TC patients in the United States with respect to patient characteristics, incidence, and survival. The results can be useful to stakeholders interested in reducing the burden of TC morbidity and mortality.