■中风后疾病综合征(POIS)很少见,包括射精后出现的一系列身体和认知症状。其发病机制和有效治疗方法尚不清楚。
■本研究旨在表征POIS的症状学,研究患者和对照组自体精液的过敏反应,并评估脱敏治疗的效果。
■分析24例POIS患者的临床特点。皮肤点刺试验,皮内试验,用自体精液进行特异性IgE检测。5例患者通过皮下注射自体精液脱敏。
■评估的结果包括POIS的临床特征;焦虑自评量表(SAS)的评分,抑郁自评量表(SDS),和症状的视觉模拟量表(VAS);皮肤反应;稀释的自体精液脱敏;以及免疫印迹和酶联免疫吸附测定的IgE反应模式。
■最常见的症状集群是一般集群,最常见的症状是极度疲劳和注意力不集中。66.67%(14/21)的患者在夜间排放后无症状或症状比性交或手淫后轻。在患者中,87.5%(21/24)有精神症状,53.85%(7/13)有性激素水平异常。高、低VAS组的SAS、SDS评分明显高于对照组。Pearson分析显示,SAS与VAS之间的相关系数为0.607(P<0.01),SDS与VAS之间的相关系数为0.490(P<0.05)。患者和健康捐献者的精液皮内测试结果均为阳性,皮肤点刺试验结果阴性,对自体精液没有特异性IgE.大多数患者(4/5)通过脱敏没有达到理想的治疗效果。
■过敏不是POIS的主要发病机制,自体精液脱敏对大多数患者无效。
■该项目包括中国最多的POIS患者,并评估了对自体精液的过敏反应和脱敏治疗的效果。没有客观的方法来评估自体精液脱敏的疗效。
■IgE介导的精液过敏不是POIS的主要发病机制,并且POIS有可能与心理因素有关。大多数患者对自体精液脱敏没有反应,POIS治疗应该是个性化的,尤其是在原因不确定的情况下。
UNASSIGNED: Postorgasmic illness syndrome (POIS) is rare and includes a cluster of physical and cognitive symptoms that occur after ejaculation. The pathogenesis and effective treatments remain unclear.
UNASSIGNED: This study aimed to characterize the symptomatology of POIS, study the allergic response of autologous semen in patients and controls, and evaluate the effects of desensitization therapy.
UNASSIGNED: The clinical characteristics of 24 Chinese patients with POIS were analyzed. Skin prick tests, intracutaneous tests, and specific IgE detection were performed with autologous semen. Five patients were desensitized via subcutaneous injections of autologous semen.
UNASSIGNED: Evaluated outcomes included the clinical features of POIS; scores of the Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), and visual analog scale (VAS) of symptoms; skin reactions; desensitization with diluted autologous seminal fluid; and the IgE reactivity patterns of immunoblotting and enzyme-linked immunosorbent assay in vitro.
UNASSIGNED: The most common symptom cluster was the general cluster, and the most prevalent symptoms were extreme fatigue and inattention. A total of 66.67% (14/21) of the patients had no symptoms or milder symptoms after nocturnal emission than after intercourse or masturbation. Of the patients, 87.5% (21/24) had psychiatric symptoms and 53.85% (7/13) had abnormal sex hormone levels. The SAS and SDS scores of the high and low VAS groups were significantly higher than those of the control group. Pearson analysis showed that the correlation coefficient between the SAS and VAS was 0.607 (P < .01) and that between the SDS and VAS was 0.490 (P < .05). The patients and healthy donors all had positive intracutaneous test results with their own semen, negative skin prick test results, and no IgE specific to autologous semen. Most patients (4/5) did not achieve ideal therapeutic effects with desensitization.
UNASSIGNED: Allergy is not the main pathogenesis of POIS, and desensitization with autologous semen is not effective for most patients.
UNASSIGNED: This project included the largest number of patients with POIS in
China and assessed the allergic response to autologous semen and the effect of desensitization therapy. There is no objective method for evaluating the efficacy of desensitization with autologous semen.
UNASSIGNED: IgE-mediated semen allergy is not the main pathogenesis of POIS, and there is a positive chance that POIS is related to psychological factors. Most patients do not respond to desensitization with autologous semen, and POIS treatment should be individualized, especially in cases with uncertain causes.