PDF(Pubmed)
Abstract：
UNASSIGNED: Postorgasmic illness syndrome (POIS) is characterized by allergic symptoms and flu-like illness after ejaculation. There are still no effective treatments for POIS.
UNASSIGNED: To report the first case of washed microbiota transplantation (WMT) to treat patient with POIS.
UNASSIGNED: Data were collected from a patient with POIS who had received 3 courses of WMT: self-rating scale of POIS symptoms, Self-rating Anxiety Scale, Self-rating Depression Scale, and Symptom Checklist 90. The patient\'s stool samples for 16sDNA sequencing were collected 1 month after WMT.
UNASSIGNED: POIS symptoms improved after WMT. Scores decreased from baseline after WMT: self-rating scale of POIS symptoms (before WMT, 16; after first, 16; after second, 8; after third, 9), Self-rating Anxiety Scale (45, 42.5, 37.5, 45), Self-rating Depression Scale (63.75, 58.75, 47.5, 50), and Symptom Checklist 90 (143, 140, 109, 149). Characteristics of the patient\'s gut microbiota changed. At the genus level, the relative abundance of beneficial bacteria increased, and some opportunistic pathogenic bacteria decreased.
UNASSIGNED: WMT may be an effective and safe choice for the treatment of patients with POIS by changing the gut microbiota of the host.
UNASSIGNED: To report the first case of washed microbiota transplantation (WMT) to treat patient with POIS.
UNASSIGNED: Data were collected from a patient with POIS who had received 3 courses of WMT: self-rating scale of POIS symptoms, Self-rating Anxiety Scale, Self-rating Depression Scale, and Symptom Checklist 90. The patient\'s stool samples for 16sDNA sequencing were collected 1 month after WMT.
UNASSIGNED: POIS symptoms improved after WMT. Scores decreased from baseline after WMT: self-rating scale of POIS symptoms (before WMT, 16; after first, 16; after second, 8; after third, 9), Self-rating Anxiety Scale (45, 42.5, 37.5, 45), Self-rating Depression Scale (63.75, 58.75, 47.5, 50), and Symptom Checklist 90 (143, 140, 109, 149). Characteristics of the patient\'s gut microbiota changed. At the genus level, the relative abundance of beneficial bacteria increased, and some opportunistic pathogenic bacteria decreased.
UNASSIGNED: WMT may be an effective and safe choice for the treatment of patients with POIS by changing the gut microbiota of the host.
摘要：
■射精后疾病综合征（POIS）的特征是过敏症状和流感样疾病。目前尚无有效的POIS治疗方法。
■报告首例洗涤微生物群移植（WMT）治疗POIS患者。
■数据来自接受3个疗程WMT的POIS患者：POIS症状自评量表，焦虑自评量表,抑郁自评量表,症状检查表90.WMT后1个月收集患者粪便样本进行16sDNA测序。
■WMT后POIS症状有所改善。WMT后得分较基线下降：POIS症状自评量表(WMT前，16；在第一次之后，16；第二次之后，8；第三之后，9),焦虑自评量表（45，42.5，37.5，45），抑郁自评量表(63.75,58.75,47.5,50),和症状清单90(143、140、109、149)。患者肠道菌群特征发生改变。在属一级，有益细菌的相对丰度增加，一些机会致病菌减少。
■WMT可能是通过改变宿主肠道菌群来治疗POIS患者的有效且安全的选择。
■报告首例洗涤微生物群移植（WMT）治疗POIS患者。
■数据来自接受3个疗程WMT的POIS患者：POIS症状自评量表，焦虑自评量表,抑郁自评量表,症状检查表90.WMT后1个月收集患者粪便样本进行16sDNA测序。
■WMT后POIS症状有所改善。WMT后得分较基线下降：POIS症状自评量表(WMT前，16；在第一次之后，16；第二次之后，8；第三之后，9),焦虑自评量表（45，42.5，37.5，45），抑郁自评量表(63.75,58.75,47.5,50),和症状清单90(143、140、109、149)。患者肠道菌群特征发生改变。在属一级，有益细菌的相对丰度增加，一些机会致病菌减少。
■WMT可能是通过改变宿主肠道菌群来治疗POIS患者的有效且安全的选择。
