目的:通过收集和评价文献,评价药师干预2型糖尿病患者的效果。
方法:在六个数据库中进行了系统搜索,包括CNKI,万方数据,VIP,PubMed,WebofScience,和Cochrane图书馆,2001年1月至2023年1月。研究了评估药师干预对2型糖尿病患者临床结果的随机对照试验。数据提取并使用RevMan5.4版软件进行分析。
结果:共纳入35项研究,涉及4827例患者。荟萃分析表明,药剂师干预对改善患者HbA1c有影响(MD=-0.70),LDL-C(MD=-5.51),SBP(MD=-4.58),DBP(MD=-1.90],BMI(MD=-0.47)和FBG(MD=-19.82),但是该研究没有证据表明药剂师干预可以显着改善HDL-C(MD=-0.61),TC(MD=-5.12)或TG(MD=-3.14)。此外,用药依从性明显提高。
结论:药师干预显著改善了HbA1c,BP,和LDL-C控制水平,BMI,和2型糖尿病患者的药物依从性,但是这项研究没有证据表明药剂师干预措施显着改善了HDL-C,TC,或TG。
结论:有效的药师干预措施对改善2型糖尿病患者的临床结局很重要。
OBJECTIVE: To evaluate the effects of
pharmacist interventions in type-2 diabetes patients by collecting and evaluating literature.
METHODS: A systematic search was conducted across six databases, including CNKI, Wanfang Data, VIP, PubMed, Web of Science, and Cochrane Library, from January 2001 to January 2023. Randomized controlled trials evaluating the clinical outcomes of
pharmacist interventions on type-2 diabetes patients were searched, and data were extracted and analysed by RevMan version 5.4 software.
RESULTS: A total of 35 studies involving 4827 patients were included. Meta-analysis demonstrated that
pharmacist interventions had an influence on improving patients\' HbA1c (MD=-0.70), LDL-C (MD=-5.51), SBP (MD=-4.58), DBP (MD=-1.90], BMI (MD=-0.47) and FBG (MD=-19.82), but there was no evidence from the study that
pharmacist interventions could significantly improve HDL-C (MD=-0.61), TC (MD=-5.12) or TG (MD=-3.14). In addition, medication adherence was significantly improved.
CONCLUSIONS: Pharmacist interventions significantly improved HbA1c, BP, and LDL-C control levels, BMI, and medication adherence in type-2 diabetes patients, but there was no evidence from this study that pharmacist interventions significantly improved HDL-C, TC, or TG.
CONCLUSIONS: Effective pharmacist interventions are important to improve type-2 diabetes patients\' clinical outcomes.