目的:本研究旨在探索微泡与微波消融(MWA)之间的相互作用。
方法:研究采用定制的体模(体外)和新西兰白兔(体内)。在体模(2×105颗粒mL-1)和兔肝脏(静脉注射0.05mL/kgSonoVue)中有或没有微泡的情况下进行MWA。在MWA期间,K型热电偶探头用于监测MWA引起的温度升高。超声造影成像(CEUS)用于监测和分析微泡信号强度。在MWA之后,评估消融区体积,并比较有微泡和无微泡组之间的差异.
结果:在幻影模型和兔子中,微泡对MWA没有显着影响,包括消融范围和MWA引起的温度升高。在充满微泡的幻影和兔子肝脏中,MWA导致在消融时间内形成逐渐扩大的微泡缺陷区域。温度的升高导致微泡的破坏。
结论:微泡对MWA无显著影响。然而,MWA以温度依赖性方式诱导微气泡的破坏。因此,当使用CEUS实时监测MWA期间的消融范围时,微泡的低耐热性是不可忽视的障碍。
OBJECTIVE: This study aimed to explore the interactions between microbubbles and microwave ablation (MWA).
METHODS: The study employed custom-made
phantoms (in vitro) and white New Zealand rabbits (in vivo). MWA was performed with or without microbubbles in the
phantoms (2 × 105 particles mL-1) and rabbit livers (intravenous injection of 0.05 mL/kg SonoVue). During the MWA, K-type thermocouple probes were used to monitor the MWA-induced temperature increase. Contrast-enhanced ultrasound imaging (CEUS) was used to monitor and analyze the microbubbles signal intensity. After MWA, the ablation-zone volumes were evaluated and compared between the groups with and without microbubbles.
RESULTS: In both the phantom models and rabbits, microbubbles showed no significant influence on MWA, including the ablation range and MWA-induced temperature increase. In
phantoms and rabbit livers filled with microbubbles, MWA caused the formation of a gradually expanding microbubble-defect region over the ablation time. An increase in the temperature caused microbubble destruction.
CONCLUSIONS: Microbubbles had no significant influence on MWA. However, MWA induced the destruction of microbubbles in a temperature-dependent manner. Thus, the poor thermotolerance of microbubbles is a non-negligible barrier when using CEUS to monitor the ablation range during MWA in real-time.