背景:缺乏有效的治疗方法来对抗视黄醇诱导的皮肤刺激。
目的:本研究旨在研究三种潜在缓解剂的功效:(i)植物甾醇/辛基十二烷基月桂酰谷氨酸(PLG),(ii)由神经酰胺三和胆固醇组成的生理脂质混合物(PLM),和(iii)烟酰胺,改善视黄醇引起的刺激。
方法:闭合性人类斑贴试验,跨越5天,对18名年龄在23至40岁之间的中国参与者进行了研究。它是随机设计的,双盲,和车辆对照研究。在测试前和测试后采用临床医生红斑评估(CEA)和仪器评估。随后,为期4周的消费者使用测试,在自然界中随机和双盲,被处决以证实PLG的舒缓作用。
结果:来自CEA和生物工程评估的数据显示,与车辆控制相比,2%PLG和5%PLM均明显抑制了视黄醇诱导的皮肤红斑和炎症。值得注意的是,PLG优于PLM。相反,3%的烟酰胺不能缓解视黄醇引起的不适。随后的消费者使用测试证实,使用2%PLG的治疗比使用单独的载体的治疗具有更好的耐受性。
结论:据我们所知,这项研究首次证实生理脂质可有效减轻视黄醇诱导的刺激.鉴于它们对抗视黄醇引起的刺激的能力,生理脂质,特别是PLG,建议纳入视黄醇方案。此外,Visia-CRa*值可以作为解释斑贴试验结果的可靠客观指标.
BACKGROUND: There is a dearth of effective treatments to counter retinol-induced skin irritation.
OBJECTIVE: This study aimed to investigate the efficacy of three potential mitigants: (i) phytosteryl/octyldodecyl lauroyl glutamate (PLG), (ii) a physiologic lipid mixture (PLM) comprised of ceramide three and cholesterol, and (iii) niacinamide, in ameliorating irritation instigated by retinol.
METHODS: An occlusive human patch test, spanning 5 days, was undertaken on 18 Chinese participants aged between 23 and 40. It was designed as a randomized, double-blind, and vehicle-controlled study. Clinician erythema assessment (CEA) and instrumental evaluations were employed pre and post-test. Subsequently, a 4-week consumer in-use test, randomized and double-blind in nature, was executed to substantiate the soothing effects of PLG.
RESULTS: Data from CEA and bioengineering assessments revealed that, in comparison to the vehicle control, both 2% PLG and 5% PLM notably curbed retinol-induced skin erythema and inflammation. Notably, PLG outperformed PLM. Conversely, 3% niacinamide did not offer relief against retinol-induced discomfort. The subsequent consumer in-use test affirmed that treatments with 2% PLG were better tolerated than those with the vehicle alone.
CONCLUSIONS: To the best of our knowledge, this study represents the first confirmation that physiologic lipids effectively mitigate retinol-induced irritation. Given their capacity to counter retinol-induced irritation, physiologic lipids, particularly PLG, are recommended for incorporation in retinol regimens. Additionally, the Visia-CR a* value can serve as a robust objective measure for interpreting patch test outcomes.