背景:在不孕症患者中使用捐赠的卵母细胞(DO)进行体外受精(IVF)治疗已得到普遍认可,患有多囊卵巢综合征(PCOS)的女性可以作为供体患者参加卵母细胞捐献计划。然而,作为受者的PCOS患者的妊娠结局和后代随访情况尚不清楚.本研究旨在比较PCOS和非PCOS受体后代的妊娠结局和随访情况。
方法:这是一项回顾性队列研究,包括62例接受卵母细胞接收计划的患者,分为两组:I组,PCOS卵母细胞受体(n=30);第二组,非PCOS接受者(n=32)。检查了医疗记录,和受精率,乳沟,比较了PCOS和非PCOS组的优质胚胎和胚泡.植入率,怀孕,异位妊娠,早期流产,多胎妊娠,和后代结局是使用组间的第一个单一玻璃化升温胚泡移植(SVBT)分析计算的。
结果:PCOS和非PCOS患者的平均受者年龄和体重指数(BMI)为(36.3±2.6vs.36.2±2.8和23.4±3.9vs.23.7±4.0),分别为(P>0.05)。受精,乳沟,优质胚胎和囊胚率在PCOS组和非PCOS组之间无显著差异.植入率,怀孕,异位妊娠,早期流产,多胎妊娠的SVBT在PCOS组和非PCOS组之间没有显着差异。并发症的发生率,如先兆子痫或妊娠糖尿病,PCOS组和非PCOS组相似(11.8%vs.11.1%,5.9%对5.5%;P>0.05)。早产也相似(11.8%vs.16.7%,P>0.05)。供体卵母细胞更有可能通过剖宫产术分娩。(80.0%vs.86.7%:P>0.05)。平均胎龄,出生体重,在足月分娩期间,两组之间的身高和身高具有可比性.
结论:PCOS组和非PCOS组的妊娠结局和后代随访没有差异。
BACKGROUND: The use of donated oocytes (DO) for in vitro fertilization(IVF) treatment in patients with infertility is generally recognized, and females with polycystic ovarian syndrome (PCOS) can participate in oocyte donation programs as donor patients. However, the pregnancy outcomes and offspring follow-up in patients with PCOS as the recipients are unclear. This study was to compare the pregnancy outcomes and follow-up of offspring in PCOS and non-PCOS receptor.
METHODS: This was a retrospective cohort study of 62 patients undergoing the oocyte reception program were separated into 2 groups: Group I, PCOS oocyte recipients (n = 30); Group II, non-PCOS recipients (n = 32). Medical records were reviewed, and rates of fertilization, cleavage, high-quality embryos and blastocysts were compared between PCOS and non-PCOS groups. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, multiple pregnancies, and offspring outcomes were calculated using the first single vitrified-warmed blastocyst transfer (SVBT) analysis between the groups.
RESULTS: The average recipient age and body mass index (BMI) of PCOS and non-PCOS patients was (36.3 ± 2.6 vs. 36.2 ± 2.8, and 23.4 ± 3.9 vs. 23.7 ± 4.0), respectively (P > 0.05). The fertilization, cleavage, high-quality embryos and blastocyst rates were not significantly different between the PCOS and non-PCOS groups. Rates of implantation, pregnancy, ectopic pregnancy, early abortion, and multiple pregnancies were not significantly different in SVBT between the PCOS and non-PCOS groups. The incidence of complications, such as pre-eclampsia or gestational diabetes, between PCOS and non-PCOS groups was similar (11.8% vs.11.1%, 5.9% vs.5.5%; P > 0.05). Preterm births were also similar (11.8% vs.16.7%, P > 0.05). Donor oocytes are more likely to be delivered via cesarean Sect. (80.0% vs. 86.7%: P > 0.05). The mean gestational age, birth weight, and height were comparable between the 2 groups during full-term delivery.
CONCLUSIONS: There was no difference in the pregnancy outcomes and follow-up of the offspring between the PCOS and non-PCOS groups.