The global pandemic caused by the coronavirus disease 2019 not only exposed the fragility of global preparedness and response to public health emergence, but also illustrated the fragmentation and gaps of research and development ecosystem. This emphasizes the need for planned actions against the potentiality of new pandemics and requires research to better understand how viruses bridge the animal/human divide making human-to-human transmission of new diseases possible. Major challenges to response to new epidemics under the current health framework reside in the so called 4-CC approach that focuses on Concept, Communication, Coherence, and Continuity. There is a need to also add a One Health perspective with emphasis on governance, surveillance, capacity building and multi-disciplinary research to achieve a holistic and better integrated system. Using a regulatory framework to equip professionals might facilitate the function of a multi-sector approach that recognizes the value of their mandates and a One Health approach in their work. Collaborative, multisectoral actions under the global regulations and guidance would make evidence-based One Health approaches sustainable and accessible to everyone.

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As a result of rapid economic growth over the previous three decades, China has become the second largest economy worldwide since 2010. However, as a developing country with the largest population, this rapid economic growth primarily based on excessive consumption and waste of resources. Thus, China has been facing particularly severe ecological and environmental problems in speeding up industrialization and urbanization. The impact of the health risk factors is complex and difficult to accurately predict. Therefore, it is critical to investigate potential threats in the context of the human-animal-environment interface to protect human and animal health. The \"One Health\" concept recognizes that human health is connected to animal and environmental health. This review primarily discusses specific health problems in China, particularly zoonoses, and explains the origin and development of the One Health approach, as well as the importance of a holistic approach in China.