背景:新的每日持续性头痛(NPDH)是一种罕见的原发性头痛,高度致残。NDPH的病理生理学尚不清楚,我们旨在通过功能磁共振成像(fMRI)分析揭示NDPH的潜在机制。
方法:在这项横断面研究中,招募了30名NDPH患者和30名健康对照(HCs)。使用GE3.0T系统获得所有参与者的血氧水平依赖性(BOLD)序列。我们表演了ReHo,ALFF(常规频段:0.01-0.08Hz,slow-5:0.01-0.027Hz,slow-4:0.027-0.073Hz)和基于种子的NDPH和HC组的全脑功能连接(FC)分析。ReHo的性别差异分析,ALFF,在NDPH组中进行FC值。我们还对ReHo,ALFF,FC值和临床特征(疼痛强度,疾病持续时间,HIT-6、GAD-7、PHQ-9和PSQI评分)。
结果:均增加了ReHo(PFWE-corr=0.012)和ALFF值(0.01-0.08Hz,PFWE-corr=0.009;0.027-0.073Hz,与HC组相比,NDPH组发现左枕中回(MOG_L)的PFWE-corr=0.044)。两组之间的FC图没有显着差异。与HC组相比,在ReHo中没有发现差异(p=0.284),ALFF(p=0.246),NDPH组MOG_L的FC(p=0.118)z得分。ReHo也没有性别差异(p=0.288),ALFF(p=0.859),NDPH患者MOG_L的FCz评分(p=0.118)。ReHo之间没有相关性,ALFF,Bonferroni校正后的FCz评分和临床特点(p<0.05/18)。
结论:患有NDPH的患者可能存在视觉系统异常激活。异常视觉激活可能主要发生在经典频带的高频带。在NDPH患者中没有发现大脑活动的性别差异。
BACKGROUND: New daily persistent headache (NPDH) is a rare primary headache that is highly disabling. The pathophysiology of NDPH is still unclear, and we aimed to reveal the underlying mechanism of NDPH through functional magnetic resonance imaging (fMRI) analysis.
METHODS: In this cross-sectional study, thirty patients with NDPH and 30 healthy controls (HCs) were recruited. The blood oxygen level-dependent (BOLD) sequences of all participants were obtained using the GE 3.0 T system. We performed ReHo, ALFF (conventional band: 0.01-0.08 Hz, slow-5: 0.01-0.027 Hz, slow-4: 0.027-0.073 Hz) and seed-based to the whole brain functional connectivity (FC) analysis in the NDPH and HC groups. The sex difference analysis of ReHo, ALFF, and FC values was conducted in the NDPH group. We also conducted Pearson\'s correlation analysis between ReHo, ALFF, FC values and clinical characteristics (pain intensity, disease duration, HIT-6, GAD-7, PHQ-9, and PSQI scores).
RESULTS: Both increased ReHo (PFWE-corr = 0.012) and ALFF values (0.01-0.08 Hz, PFWE-corr = 0.009; 0.027-0.073 Hz, PFWE-corr =0.044) of the left middle occipital gyrus (MOG_L) were found in the NDPH group compared to the HC group. There was no significant difference in FC maps between the two groups. Compared to the HC group, no difference was found in ReHo (p = 0.284), ALFF (p = 0.246), and FC (p = 0.118) z scores of the MOG_L in the NDPH group. There was also no sex difference in ReHo (p = 0.288), ALFF (p = 0.859), or FC z score (p = 0.118) of the MOG_L in patients with NDPH. There was no correlation between ReHo, ALFF, FC z scores and clinical characteristics after Bonferroni correction (p < 0.05/18).
CONCLUSIONS: Patients with NDPH may have abnormal activation of the visual system. Abnormal visual activation may occur mainly in higher frequency band of the classical band. No sex differences in brain activity were found in patients with NDPH.