目的:我们旨在确定缺铁性贫血与慢性每日头痛之间的关系。
方法:这项病例对照研究是在Dehradun的三级护理中心进行的,印度。随机选择100名患有慢性每日头痛的患者进行研究,对照组数量相等。根据第三版《国际头痛疾病分类》诊断出慢性每日头痛的亚组。评估研究参与者的缺铁性贫血。
结果:患者的平均年龄为51.1±22.1岁。男女比例为1:1.08。62例(62%)出现慢性偏头痛,23例紧张型头痛(23%),15例(15%)患者出现新的每日持续性头痛。大多数患者(96%)患有轻度至中度的慢性每日头痛。所有患者的慢性每日头痛持续时间长。64(64%)患者患有贫血,其中51(51%)患者患有缺铁性贫血。缺铁性贫血与慢性每日头痛显著相关(p<0.001),但不是它的类型,子类型,和持续时间。严重缺铁性贫血与慢性每日头痛的严重程度显著相关(p=0.021)。血清铁,铁蛋白,总铁结合能力,转铁蛋白饱和度也与慢性每日头痛有显著关联(每个p<0.05),但不是它的类型,子类型,持续时间,和严重性。Logistic回归分析显示缺铁性贫血,总铁结合能力,和转铁蛋白饱和度与慢性每日头痛有独立的关联(每个p<0.05)。
结论:缺铁性贫血与慢性每日头痛有独立关联。严重缺铁性贫血与慢性每日头痛的严重程度有关。
OBJECTIVE: We aimed to determine the association between iron deficiency anemia and chronic daily headache.
METHODS: This
case-control study was conducted in a tertiary care center in Dehradun, India. One hundred patients with chronic daily headache were randomly selected for the study with an equal number of controls. Subsets of chronic daily headache were diagnosed as per the 3rd edition of the International Classification of Headache Disorders. The study participants were assessed for iron deficiency anemia.
RESULTS: The mean age of the patients was 51.1 ± 22.1 years. Male: female ratio was 1:1.08. Chronic migraine was present in 62 (62%), tension-type headache in 23 (23%), and new daily persistent headache in 15 (15%) patients. The majority (96%) of patients had chronic daily headache of mild to moderate severity. Chronic daily headache was of long duration in all patients. Sixty-four (64%) patients had anemia of which 51 (51%) patients had iron deficiency anemia. Iron deficiency anemia showed a significant association with chronic daily headache (p < 0.001), but not with its type, subtype, and duration. Severe iron deficiency anemia had a significant association with the severity of chronic daily headache (p = 0.021). Serum iron, ferritin, total iron-binding capacity, and transferrin saturation also had a significant association with chronic daily headache (p < 0.05 for each), but not with its type, subtype, duration, and severity. Logistic regression analysis showed that iron deficiency anemia, total iron-binding capacity, and transferrin saturation had an independent association with chronic daily headache (p < 0.05 for each).
CONCLUSIONS: Iron deficiency anemia had an independent association with chronic daily headache. Severe iron deficiency anemia was related to the severity of chronic daily headache.