背景：尽管在痣（NS）中可以出现各种良性和恶性肿瘤，继发性肿瘤的人口统计学和临床病理特征在不同的已发表报告中有所不同.这项研究的目的是更好地了解继发于NS的肿瘤的特征。
方法：回顾性分析2010-2022年重庆医科大学附属第一医院皮肤科和重庆医科大学附属第一医院黔江医院确诊的NS患者。还对NS继发肿瘤的病例系列进行了文献综述。
结果：我们回顾性分析了2000年以来发表的关于NS继发肿瘤的文献，共443例，并仔细研究了自2010年以来来自多个中心的NS肿瘤病例，共54例。本研究共497例，90.3%为良性肿瘤（n=449），其余为恶性肿瘤(9.7%,n=48）。乳头状浆囊腺瘤是最常见的良性肿瘤，其次是三毛母细胞瘤和三毛鞘瘤。基底细胞癌是NS最常见的继发性恶性肿瘤，其次是鳞状细胞癌。其中2例发生转移。高加索人的继发性恶性肿瘤比西班牙裔和亚洲人的年龄更早。
结论：本研究是对NS继发肿瘤的最大分析。在NS的继发性肿瘤中可以看到种族差异，并且可能导致种族之间的医疗保健差异。
BACKGROUND: Although various benign and malignant tumors can arise in nevus sebaceus (NS), the demographic and clinicopathological features of the secondary tumors vary among different published reports. The aim of this study was to obtain a better understanding of the features of tumors secondary to NS.
METHODS: A multicenter study was performed by reviewing patients diagnosed with NS from the Dermatology Department of the First Affiliated Hospital of Chongqing Medical University and Qijiang Hospital of the First Affiliated Hospital of Chongqing Medical University from 2010 to 2022. A literature review of case series of secondary tumors arising in NS was also conducted.
RESULTS: We retrospectively analyzed the literature on tumors secondary to NS published since 2000, with a total of 443 cases, and carefully studied cases of tumors arising in NS from multiple centers since 2010, with a total of 54 cases. There were 497 cases in this study; 90.3% were benign tumors (n = 449), and the rest were malignant tumors (9.7%, n = 48). Syringocystadenoma papilliferum was the most common benign tumor, followed by trichoblastoma and trichilemmoma. Basal cell carcinoma was the most common secondary malignant tumor to NS, followed by squamous cell carcinoma. Two of these cases developed metastasis. Secondary malignancies developed at an earlier age in Caucasians than in Hispanics and Asians.
CONCLUSIONS: The present study is the largest analysis of tumors secondary to NS. Racial differences were seen in secondary tumors to NS and may contribute to healthcare disparities between races.
