背景:先前的研究报告说,食用蘑菇与较低的高尿酸血症发生率有关,但是关于这种关联的证据有限。我们进行了一项合作研究,以调查中老年人群蘑菇摄入量与高尿酸血症之间的关系。
方法:我们使用了美国国家健康和营养检查调查(NHANES)(2007-2018)和日本国家长寿科学研究所-衰老纵向研究(NILS-LSA)(1997-2012)的数据。通过NHANES中一天或两天的饮食回忆和NILS-LSA中三天的饮食记录来测量蘑菇的消费量(g/天)。在NHANES中,男性和女性使用尿酸水平>420μmol/L和>350μmol/L定义高尿酸血症,分别;在NILS-LSA中,在基线和随访调查时反复测量血清尿酸.高尿酸血症定义为男性尿酸水平>416.4μmol/L,女性≥356.9μmol/L。进行了NHANES中的逻辑回归模型(横截面)和NILS-LSA中的广义估计方程(纵向)。
结果:共纳入5,778名NHANES参与者(平均(SD)年龄:53.2(9.6)岁)和1,738NILS-LSA(平均(SD)年龄:53.5(11.2)岁)。NHANES中5.7%的参与者食用蘑菇,NILS-LSA中81.2%食用蘑菇。在NHANES男性和女性中,我们没有观察到蘑菇摄入量和高尿酸血症之间的显著关联。然而,在NILS-LSA中,与非消费者相比,在65岁以下的男性中,蘑菇摄入量较高与高尿酸血症发生率较低相关。非消费者的调整后赔率比(95%CI),中间的参与者,蘑菇的最高消费量为1.00(参考),0.77(0.44,1.36),和0.55(0.31,0.99),分别(P-趋势=0.036)。在NILS-LSA的女性中未发现关联。
结论:在日本男性中,食用蘑菇与高尿酸血症发生率较低相关。
BACKGROUND: Prior study reported that mushroom consumption was associated with a lower incidence of hyperuricemia, but there is limited evidence on this association. We conducted a collaborative study to investigate the association between mushroom intake and hyperuricemia in middle-aged and older populations.
METHODS: We used data from the National Health and Nutrition Examination Survey (NHANES) in the U.S. (2007-2018) and the National Institute for Longevity Sciences-Longitudinal Study of Aging (NILS-LSA) in Japan (1997-2012). Consumption of mushroom (g/day) were measured by one- or two-day dietary recall in NHANES and by 3-day dietary records in the NILS-LSA. Hyperuricemia was defined using uric acid levels as > 420 μmol/L and > 350 μmol/L in NHANES for men and women, respectively; in the NILS-LSA, serum uric acid was repeatedly measured at baseline and follow-up surveys. Hyperuricemia was defined as uric acid levels > 416.4 μmol/L for men and ≥ 356.9 μmol/L for women. Logistic regression models in NHANES (cross-sectionally) and Generalized Estimation Equations in NILS-LSA (longitudinally) were performed.
RESULTS: A total of 5,778 NHANES participants (mean (SD) age: 53.2 (9.6) years) and 1,738 NILS-LSA (mean (SD) age: 53.5 (11.2) years) were included.
Mushrooms were consumed by 5.7% of participants in NHANES and 81.2% in NILS-LSA. We did not observe a significant association between mushroom intakes and hyperuricemia in the NHANES men and women. However, in the NILS-LSA, compared to non-consumers, a higher mushroom intake was associated with a lower risk of incident hyperuricemia in men under 65 years old. The adjusted odds ratio (95% CI) for non-consumers, participants with middle, and the highest consumption of
mushrooms were 1.00 (Ref.), 0.77 (0.44, 1.36), and 0.55 (0.31, 0.99), respectively (P-trend = 0.036). No association was found in women in NILS-LSA.
CONCLUSIONS: Mushroom consumption was associated with a lower risk of incident hyperuricemia in Japanese men.