芯片上的器官是微生理系统,允许复制人体器官的关键功能,加速生命科学的创新,包括疾病建模。药物开发,精准医学。然而,由于其定义中缺乏标准,结构设计,细胞来源,模型构建,和功能验证,芯片上器官的广泛翻译应用仍然是一个挑战。"芯片上器官:肠"是中国第一个关于芯片上人体肠的团体标准,由中国生物技术学会专家共同商定并于2024年4月29日发布。本标准规定了适用范围,术语,定义,技术要求,检测方法,以及在芯片上构建人体肠道模型的质量控制。本团体标准的发布将指导机构建立,接受和执行适当的实用协议,并加速转换应用的芯片上肠道的国际标准化。
Organs-on-chips are microphysiological systems that allow to replicate the key functions of human organs and accelerate the innovation in life sciences including disease modeling, drug development, and precision medicine. However, due to the lack of standards in their definition, structural design, cell source, model construction, and functional validation, a wide range of translational application of organs-on-chips remains a challenging. \"Organs-on-chips: Intestine\" is the first group standard on human intestine-on-a-chip in
China, jointly agreed and released by the experts from the Chinese Society of Biotechnology on 29th April 2024. This standard specifies the scope, terminology, definitions, technical requirements, detection methods, and quality control in building the human intestinal model on a chip. The publication of this group standard will guide the institutional establishment, acceptance and execution of proper practical protocols and accelerate the international standardization of intestine-on-a-chip for translational applications.