背景:一碳代谢(OCM)营养素(蛋氨酸,叶酸,维生素B6和维生素B12)和阿尔茨海默病(AD)仍然没有定论。
目的:本研究旨在探讨膳食OCM营养素与AD后续风险的关系。并进一步评估了AD遗传风险高的参与者是否可能从饮食OCM营养素中受益。
方法:我们根据UKBiobank分析了192,214名参与者的数据,这些参与者完成了至少一份24小时饮食问卷,并且以前没有AD病史。使用McCance和Widdowson的《食物组成》和USDA的《饮食研究食物和营养数据库》计算营养素摄入量。应用具有受限三次样条的Cox比例模型来探索关联。
结果:中位随访时间为13.35年,确定了959例AD(41例早发性病例和918例晚发性病例)。与低摄入量OCM组(四分位数1)相比,高摄入量OCM组(四分位数4)的参与者患AD的风险降低.蛋氨酸的相应危险比(HR)和95%CI,叶酸,维生素B6和维生素B12的摄入量分别为0.66(0.54,0.80),0.71(0.58,0.87),0.71(0.59,0.87),和0.77(0.64,0.93),分别。在晚发性AD中观察到类似的关联。在早发性AD中,高蛋氨酸和维生素B12摄入量与70%(HR=0.30,95%CI:0.10,0.86)和71%(HR=0.29,95%CI:0.09,0.96)的风险降低相关,分别。与高风险人群相比,低遗传风险和高OCM营养素摄入量的参与者AD风险降低>75%。低摄入量参与者。
结论:在这项前瞻性队列研究中,我们发现,OCM营养素的高摄入量与AD的风险降低相关.具有高AD遗传风险的参与者更有可能从饮食OCM营养素摄入中受益。
BACKGROUND: The associations between one-carbon metabolism (OCM) nutrients (
methionine, folate, vitamin B6, and vitamin B12) and Alzheimer\'s disease (AD) remains inconclusive.
OBJECTIVE: This study aims to investigate the association of dietary OCM nutrients with the subsequent risk of AD, and further assessed whether participants with a high genetic risk for AD might benefit from dietary OCM nutrients.
METHODS: We analyzed data from 192,214 participants who completed at least one 24-hour dietary questionnaire and had no previous history of AD based on the UK Biobank. Nutrients intake was calculated using McCance and Widdowson\'s The Composition of Food and USDA\'s Food and Nutrient Database for Dietary Studies. Cox proportional models with restricted cubic splines were applied to explore the associations.
RESULTS: Over a median follow-up of 13.35 years, 959 cases of AD (41 early-onset cases and 918 late-onset cases) were identified. Compared to those in the low-intake OCM group (quartile 1), participants in the high-intake OCM group (quartile 4) had a reduced risk of developing AD. The corresponding hazard ratios (HRs) and 95% CI for
methionine, folate, vitamin B6, and vitamin B12 intake were 0.66 (0.54, 0.80), 0.71 (0.58, 0.87), 0.71 (0.59, 0.87), and 0.77 (0.64, 0.93), respectively. Similar associations were observed in late-onset AD. In early-onset AD, high
methionine and vitamin B12 intake were associated with a 70% (HR = 0.30, 95% CI: 0.10, 0.86) and 71% (HR = 0.29, 95% CI: 0.09, 0.96) reduction in risk, respectively. Participants with low genetic risk and high OCM nutrients intake had a >75% reduced AD risk compared to high-risk, low-intake participants.
CONCLUSIONS: In this prospective cohort study, we found that higher intake of OCM nutrients is associated with a reduced risk of AD. Participants with a high genetic risk of AD are more likely to benefit from dietary OCM nutrients intake.