硫化氢(H2S)是体内三种最关键的气态信使之一。H2S供体的发现,再加上它的内生合成能力,给血液系统恶性肿瘤的治疗带来了希望.在过去的十年里,对H2S影响的调查已经扩大,特别是在心血管功能领域,炎症,感染,和神经调节。血液恶性肿瘤是指由造血细胞的异常增殖和分化引起的多种癌症。包括白血病,淋巴瘤和骨髓瘤。在这次审查中,我们深入研究了H2S与恶性血液病之间复杂的相互关系.此外,我们全面阐明了H2S及其供体复杂调节肿瘤生长进展的分子机制。此外,我们系统地研究了它们对关键方面的影响,包括扩散,入侵,血液系统恶性肿瘤的迁移能力。因此,这篇综述可能为我们理解血液系统恶性肿瘤领域H2S及其供体的前瞻性治疗意义提供新的见解.
Hydrogen sulfide (H2S) is one of the three most crucial gaseous messengers in the body. The discovery of H2S donors, coupled with its endogenous synthesis capability, has sparked hope for the treatment of hematologic malignancies. In the last decade, the investigation into the impact of H2S has expanded, particularly within the fields of cardiovascular function, inflammation, infection, and neuromodulation. Hematologic malignancies refer to a diverse group of cancers originating from abnormal proliferation and differentiation of blood-forming cells, including leukemia, lymphoma, and myeloma. In this review, we delve deeply into the complex interrelation between H2S and hematologic malignancies. In addition, we comprehensively elucidate the intricate molecular mechanisms by which both H2S and its donors intricately modulate the progression of tumor growth. Furthermore, we systematically examine their impact on pivotal aspects, encompassing the proliferation, invasion, and migration capacities of hematologic malignancies. Therefore, this review may contribute novel insights to our understanding of the prospective therapeutic significance of H2S and its donors within the realm of hematologic malignancies.