抑郁症是一种常见的精神疾病,因缺乏快感而被广泛认可,疲劳,情绪低落,and,在严重的情况下,甚至自杀倾向.光生物调节(PBM)是一种非侵入性的神经调节技术,可以治疗患有抑郁症等情绪障碍的患者。
■对十个数据库的系统搜索,包括抑郁症的随机对照试验(RCT),从图书馆建设到2023年9月25日进行。主要结果是抑郁症。次要结果是睡眠。使用RevMan(5.4版)和Stata(14.0版)进行Meta分析。进行亚组分析以确定异质性的来源。使用建议分级评估来评估证据的确定性,发展,和评估(等级)。
■从数据库中检索到三千二百六十五项研究,并筛选纳入11项试验。森林地块结果表明,PBM减轻了抑郁症(SMD=-0.55,95%CI[-0.75,-0.35],I2=46%)。但这对患者的睡眠结果没有统计学意义(SMD=-0.82,95%CI[-2.41,0.77],I2=0%,p>0.05)。亚组分析显示,s-PBM在缓解抑郁症状方面优于t-PBM。t-PBM的最佳改进是使用823nm的波长实现的,通量为10-100J/cm2,辐照度为50-100mW/cm2,辐照时间为30分钟,治疗频率<3/周,治疗次数>15次。s-PBM的最佳改进是使用808nm的波长实现的,通量≤1J/cm2,辐照度为50-100mW/cm2,辐照时间≤5min,治疗频率≥3/周,治疗次数>15次。所有结果的证据质量都是中等或非常低的,出版没有偏见。
■我们得出结论,PBM可有效减轻患者的抑郁症状。然而,目前的研究数量很少,需要进一步的研究来扩展当前的分析结果。
■https://www.crd.约克。AC.英国/PROSPERO/,CRD42023444677。
UNASSIGNED: Depression is a common mental illness that is widely recognized by its lack of pleasure, fatigue, low mood, and, in severe cases, even suicidal tendencies. Photobiomodulation (PBM) is a non-invasive neuromodulation technique that could treat patients with mood disorders such as depression.
UNASSIGNED: A systematic search of ten databases, including randomized controlled trials (RCTs) for depression, was conducted from the time of library construction to September 25, 2023. The primary outcome was depression. The secondary outcome was sleep. Meta-analysis was performed using RevMan (version 5.4) and Stata (version 14.0). Subgroup analyses were performed to identify sources of heterogeneity. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).
UNASSIGNED: Three thousand two hundred and sixty-five studies were retrieved from the database and screened for inclusion in eleven trials. The forest plot results demonstrated that PBM alleviated depression (SMD = -0.55, 95% CI [-0.75, -0.35], I2 = 46%). But it is not statistically significant for patients\' sleep outcomes (SMD = -0.82, 95% CI [-2.41, 0.77], I2 = 0%, p > 0.05). Subgroup analysis showed that s-PBM was superior to t-PBM in relieving symptoms of depression. The best improvement for t-PBM was achieved using a wavelength of 823 nm, fluence of 10-100 J/cm2, irradiance of 50-100 mW/cm2, irradiance time of 30 min, treatment frequency < 3/week, and number of treatments >15 times. The best improvement for s-PBM was achieved using a wavelength of 808 nm, fluence ≤1 J/cm2, irradiance of 50-100 mW/cm2, irradiance time ≤ 5 min, treatment frequency ≥ 3/week, number of treatments >15 times. All results had evidence quality that was either moderate or very low, and there was no bias in publication.
UNASSIGNED: We conclude that PBM is effective in reducing depression symptoms in patients. However, the current number of studies is small, and further studies are needed to extend the current analysis results.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/, CRD42023444677.