目的:探讨宫颈原发性肉瘤的临床病理特征及预后。
方法:我们确定了2002年至2020年在我们机构治疗的所有原发性宫颈肉瘤患者,并分析了其临床病理特征和预后。
结果:确定了34例患者,7例(20.6%)患者患有平滑肌肉瘤,6人(17.6%)有癌肉瘤,5人(14.7%)患有尤因肉瘤,4人(11.8%)有横纹肌肉瘤,4例(11.8%)未分化肉瘤,2例(5.9%)有腺肉瘤,2例(5.9%)子宫内膜间质肉瘤,1(2.9%)患有隆突性皮肤纤维肉瘤,1例(2.9%)患有肺泡软组织肉瘤,2例(5.9%)患有未另作说明的肉瘤。整个患者的中位年龄为43.5岁(范围,13-63).尤因肉瘤或横纹肌肉瘤患者的中位年龄为22岁(范围,13-39)和17年(范围,13-36岁),分别。分期分布为:21例(61.8%)患者的I期,第二阶段在第4期(11.8%),III期6例(17.6%),IV期3例(8.8%)。总的来说,30例(88.2%)患者接受手术治疗。中位随访时间为33.3个月(范围3.6-187.3个月)。11例患者在确诊后2年内死亡,其中大多数是癌肉瘤或未分化肉瘤患者(45.5%,5/11).在整个队列中,2年和5年OS分别为67.2%和56.9%,分别。未分化肉瘤的5年OS为25.0%,横纹肌肉瘤占50.0%,50.0%为癌肉瘤,尤因肉瘤占53.3%,57.1%为平滑肌肉瘤。
结论:宫颈肉瘤是罕见的肿瘤,具有多种组织学亚型,并遵循侵袭性病程。预后可能与肿瘤组织学和分期有关。
OBJECTIVE: To investigate the clinicopathological characteristics and prognosis of patients with primary sarcoma of the uterine cervix.
METHODS: We identified all patients with primary cervical sarcomas treated at our institution from 2002 to 2020 and analyzed the clinicopathological characteristics and prognosis.
RESULTS: 34 patients were identified, 7 (20.6%) patients had
leiomyosarcoma, 6 (17.6%) had carcinosarcoma, 5 (14.7%) had Ewing sarcoma, 4 (11.8%) had rhabdomyosarcoma, 4 (11.8%) had undifferentiated sarcoma, 2 (5.9%) had adenosarcoma, 2 (5.9%) had endometrial stromal sarcoma, 1 (2.9%) had dermatofibrosarcoma protuberans, 1 (2.9%) had alveolar soft tissue sarcoma and 2 (5.9%) had sarcoma not otherwise specified. The median age of the whole patients was 43.5 years (range, 13-63). The median age of patients with Ewing sarcoma or rhabdomyosarcoma was 22 years (range, 13-39) and 17 years (range, 13-36 years), respectively. The distribution by stage was: stage I in 21 (61.8%) patients, stage II in 4 (11.8%), stage III in 6 (17.6%) and stage IV in 3 (8.8%). Overall, 30 patients (88.2%) received surgical treatment. The median follow-up was 33.3 months (range 3.6-187.3 months). 11 patients died within 2 years after diagnosis, most of them were patients with carcinosarcoma or undifferentiated sarcoma (45.5%, 5/11). In the entire cohort, 2- and 5-year OS were 67.2% and 56.9%, respectively. 5-year OS was 25.0% for undifferentiated sarcoma, 50.0% for rhabdomyosarcoma, 50.0% for carcinosarcoma, 53.3% for Ewing sarcoma, 57.1% for
leiomyosarcoma.
CONCLUSIONS: Cervical sarcomas are rare neoplasms with multiple histological subtypes and follow an aggressive course. Prognosis may be associated with tumor histology and stage.