未经评估:本研究的目的是描述和分析诺卡心病的临床特征。
UNASSIGNED:我们从以下几个方面描述和分析了过去5年来自两个中心的诺卡病病例的临床特征:年龄和性别,诺卡氏菌物种,诺卡氏菌感染部位,试样,检测方法,并发病原体,症状,成像特征,共同条件,药敏试验,抗生素治疗/持续时间,结果,和后续行动。
未经评估:19例患者的中位年龄为64岁,四分位数间距(IQR)为56-68年。8例(42.1%)免疫功能低下[那些使用皮质类固醇的人(62.5%),使用过免疫抑制剂的人(50.0%),或患有慢性肾病(37.5%)或糖尿病(DM)(25.0%)的人]。这些病例的过多合并症包括糖尿病(10.5%),慢性肾脏病(CDK)(15.8%),慢性肺病(36.8%),和风湿性疾病(10.5%)。咳嗽和咳痰(73.7%)是诺卡心症最常见的症状。呼吸道(89.5%)是临床疾病的最常见部位。近一半(9例,47.3%)的这些患者并发感染。最常见的诺卡氏菌隔离部位是呼吸道(73.7%)。所有患者均给予抗生素治疗,其中多达63.6%的患者同时使用两种抗菌药物治疗,15.8%的患者在单一疗法下治疗,21.1%的患者同时使用三种或更多种抗菌药物治疗。
未经证实:一种罕见的危及生命的感染,心源性心脏病,影响那些患有结构性肺病或免疫抑制的患者。尽管诺卡病能够发展为严重的转移性疾病,早期识别和及时治疗通常会导致患者受益的成功结果.
UNASSIGNED: The objective of the present study was to describe and analyze the clinical characteristics of nocardiosis.
UNASSIGNED: We described and analyzed the clinical characteristics of nocardiosis cases from two centers over the past 5 years from the following aspects: age and sex, Nocardia species, sites of Nocardia infection, test specimens, detection methods, concurrent pathogens, symptoms, imaging features, co-conditions, drug susceptibility tests, antibiotic therapy/duration, outcomes, and follow-up.
UNASSIGNED: The median age of the 19 cases was 64 years, with an interquartile range (IQR) of 56-68 years. Eight cases (42.1%) were immunocompromised [those who had been on corticosteroid use (62.5%), those who had used immunosuppressants (50.0%), or those who had suffered from chronic nephrosis (37.5%) or diabetes mellitus (DM) (25.0%)]. The plethora of comorbidities of these cases included diabetes (10.5%), chronic kidney disease (CDK) (15.8%), chronic lung disease (36.8%), and rheumatic diseases (10.5%). Cough and expectoration (73.7%) was the most common symptom of nocardiosis. The respiratory tract (89.5%) was the most common site of the clinical disease. Nearly half (9 cases, 47.3%) of these patients had concurrent infections. The most common Nocardia isolation site was the respiratory tract (73.7%). All patients were given antibiotic therapies, out of whom as many as 63.6% of patients were treated with two concurrent antimicrobial agents, 15.8% of patients were treated under monotherapy and 21.1% of patients were treated with three or more concurrent antimicrobial agents.
UNASSIGNED: An uncommon life-threatening infection, nocardiosis, affects those patients with structural lung disease or immunosuppression. Although nocardiosis is capable of progressing into a serious and metastatic disease, early recognition and prompt treatment usually result in successful outcomes benefitting the patient.