The COVID-19 epidemic and government intervention measures may have adverse effects on people\'s mental health. To explore the influence of pets on the intervention of people\'s psychological problems during the COVID-19 epidemic, an online survey was carried out between April 9 and April 29, 2020. A total of 756 participants replied to this questionnaire. Mental health variables were assessed, and the comparison of behavior changes among pet owners and pets on positive mental well-being during COVID-19 epidemic. Comparative analysis was performed; compared with individuals without pets (n = 575), pet owners (n = 181) had a higher prevalence of insomnia (p = 0.006). Living in Wuhan city was a risk factor for people with psychological stress (p < 0.05). Dog owners exhibited lower than average scores of insomnia and uncertainty of infection than cat owners (p = 0.004). People with more than one pet exhibited lower than average scores of depression than having one pet (p = 0.040). For analysis of psychological effects of pets on people, the role of pets in subjective feeling and positive psychological changes of pet owner was significantly different. Pet owners relieve that psychological pressure through behavioral changes towards their pets in early stage. Pets provided positive subjective well-being and psychological effects for their owners.

SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally, SHP2 serves as an important hub to connect several intracellular oncogenic signaling pathways, such as Jak/STAT, PI3K/AKT, RAS/Raf/MAPK, and PD-1/PD-L1 pathways. Mutations and/or overexpression of SHP2 has been associated with genetic developmental diseases and cancers. Because of the role of SHP2 plays in many diseases, the development of inhibitors targeting the catalytic site in SHP2 has been pursued for more than a decade, but none has advanced to clinical development. Recent discovery of allosteric inhibitors has inspired a novel approach to selectively target SHP2 via the noncatalytic site. To date, four SHP2 allosteric inhibitors have entered clinical trials for the treatment of solid tumors. This review will provide a summary of the physiological and biological functions of SHP2 and discuss the development of nonallosteric/allosteric SHP2 inhibitors in recent years.

Global urbanization has given cause for a re-assessment of the nature and importance of the relationship between humans and domesticated animals. In densely-populated urban societies, where loneliness and alienation can be prevalent, the use of animals as human companions has taken on heightened importance. Hong Kong is the world\'s most urbanised political entity, and thus provides an ideal context for the exploration of the role of animals in the provision of companionship for human beings in cities. A web-based survey with descriptive analyses, regression, and ANOVA was conducted. Six-hundred-and-forty-seven companion animal owners and 312 non-owners completed the survey that examined their socio-demographic information, companion animal ownership status, and physical-psychosocial well-being. The statistically significant findings appear to suggest that socio-demographic variables (i.e., age, gender, housing, and education level) have stronger predictive values than companion animal ownership status with respect to the well-being of people in Hong Kong. Due the unique environmental features in Hong Kong, the positive impacts of companion animal ownership on the physical well-being of owners may be limited by the city\'s cramped living space and the limited number of people who own companion animals. However, results suggested that companion animals may still serve as a social lubricant between the owners and their significant others, thereby playing a heightened role significant role in enhancing general social connectedness in a metropolis. Given the importance of animals as human companions, it is suggested that relevant administrative agencies need to consider the development of policies and facilities which are conducive to both the maintenance and development of the bonds between humans and their companion animals and the physical and psychosocial health of both.

BACKGROUND: Pet ownership in China has been steadily increasing over recent years. However, the risk of pet-associated zoonotic infection with the protozoan parasite Toxoplasma gondii remains poorly defined.
METHODS: In a cross-sectional survey, we have determined the seroprevalence of T. gondii infection in pet dogs and cats, and pet owners. Serum samples were collected from 360 pets and 460 corresponding pet owners between March 2016 to June 2017, from Shandong province, eastern China. Sera from the animals were tested for anti-T. gondii antibodies using an indirect haemagglutination assay (IHA) and from the pet owners using an enzyme-linked immunosorbent assay (ELISA).
RESULTS: Antibodies against T. gondii were detected in 67 of 360 (18.61%) pets. Seroprevalence of T. gondii in pet cats and dogs was 21.67% and 15.56%, respectively. IgG and IgM antibodies were detected in 79 (17.17%) and 4 (0.87%) of pet owners, respectively; with a total of 83 of 460 (18.04%) pet owners testing seropositive for T. gondii. Our seroprevalence data also suggest that cat owners in general and female pet owners in particular could face a higher risk of acquiring T. gondii infection.
CONCLUSIONS: Significant levels of anti-T. gondii antibodies were detected in the pets and their owners in Shandong province, eastern China, indicating a potential zoonotic risk. Prophylactic measures should be implemented to reduce the risk of pet owner\'s exposure to T. gondii infection.

The aim of this meta-analysis was to systematically examine the efficacy of animal-assisted intervention (AAI) for cognitive impairment patients. PubMed, Embase, the Cochrane library, PsycINFO, and Web of Science databases were searched up to June 2017 to collect studies related to AAI conducted in patients with cognitive impairment. Five randomized controlled trials (RCTs) and five quasi-randomized controlled trials (quasi-RCTs) involving 413 participants were included. Compared with control groups, AAI groups exhibited significantly fewer behavioral and psychological symptoms of dementia (BPSD), especially depression and agitation. In both the short and long term, AAI had beneficial effects on BPSD in cognitive impairment patients. However, no significant improvements were found in daily living activities, quality of life or cognitive score. The present meta-analysis showed that AAI can be effective in reducing BPSD in patients with cognitive impairment.

The study aims to determine if and how pet availability and engagement predicted depression in older adults. The prediction can be unconditional or independent of the sociodemographic characteristics of the older adult and/or conditional or dependent on the characteristics. These predictions rest on the contribution of resources pooled from older adults, their spouses, and pets, according to ecological theory.
The present study analyzed the effects of pet availability and engagement based on a survey of 340 older adults in Hong Kong, China.
Pet engagement but not pet availability manifested a significant negative effect on depression unconditionally. In addition, pet availability and engagement indicated some significant negative effects conditionally, including living with the spouse as a condition.
For preventing depression in older adults, promoting their pet availability and engagement is promising. Particularly, the promotion would be more effective for older adults living with their spouses and being more resourceful than for others.

It is a worldwide trend that more households are having pets or companion animals. Hence, there has been an increasing number of animal lovers experience companion animal loss bereavement. This form of bereavement has not been explored in Chinese societies. We conducted a qualitative study using in-depth interviews with 31 animal lovers and recruited through convenience and snowball sampling in Hong Kong. Companion animal loss bereavement appears to share similar features to other forms of bereavement but also has its unique features. The intensity of grief seemed to be affected by factors like the strength of the human-animal bond, lack of empathy from closed ones, being married without children, and euthanasia decision. Although the bereavement was distressful for many of our participants, many of them gradually achieved personal growth from their loss experience. We have identified seven common themes from the interview data and through self-reliance, social-supported, or professional-supported coping behaviors, people bereaved by animal loss can achieve growth from their experience. This study shows that postbereavement growth is possible from pet loss bereavement when appropriate coping strategies are adopted by the bereaved but some professional help may be needed.