■功能磁共振成像(fMRI)已被广泛用于研究睡眠研究领域的灰质(GM)中的神经活动,但是白质(WM)中的神经活动受到的关注要少得多。当前的研究旨在检验我们的假设,即WM功能异常与睡眠质量差有关。
■对从HumanConnectomeProject数据集中提取的78名健康成年人进行了K均值聚类分析,以提取稳定的WM功能网络(WM-FN)和GM-FN。WM-FN内部以及WM-和GM-FN之间的功能连通性差异,以及睡眠质量好和差的组之间的功率谱(匹兹堡睡眠质量指数(PSQI)<6,日间功能障碍=0)和睡眠质量差组(PSQI>6,日间功能障碍>0)。此外,评估了睡眠质量与WM-FN功能特征改变之间的线性关系。
■中间和表面WM-FN之间的功能连接,睡眠不良者WM-和GM-FN之间的短期和长期功能连接降低,与PSQI评分呈负相关。整个右感觉运动WM网络的平均振幅,睡眠不良者的高频带和低频带较高,并且与PSQI评分呈正相关。
■WM功能异常与睡眠质量差有关。在未来的研究中,需要研究不良睡眠者中WM-FN功能改变的神经生物学机制。
UNASSIGNED: Functional magnetic resonance imaging (fMRI) has been widely adopted to investigate the neural activity in gray matter (GM) in the field of sleep research, but the neural activity in white matter (WM) has received much less attention. The current study set out to test our hypothesis that WM functional abnormality is associated with poor sleep quality.
UNASSIGNED: K-means clustering analysis was performed on 78 healthy adults drawn from the Human Connectome Project dataset to extract stable WM functional networks (WM-FNs) and GM-FNs. The differences in functional connectivity within WM-FNs and between WM- and GM-FNs, as well as the power spectrum between good sleep quality group (Pittsburgh Sleep Quality Index (PSQI) <6, daytime dysfunction = 0) and poor sleep quality group (PSQI >6, daytime dysfunction >0) were examined between groups with good and poor sleep quality. Additionally, linear relationships between sleep quality and altered functional characteristics of WM-FNs were evaluated.
UNASSIGNED: Functional connectivity between middle and superficial WM-FNs, short- and long-range functional connectivity between WM- and GM-FNs were decreased in poor sleepers and negatively correlated with PSQI score. The mean amplitudes of right sensorimotor WM networks at whole, high and low frequency bands were higher in poor sleepers and were positively correlated with PSQI score.
UNASSIGNED: WM functional abnormality is associated with poor sleep quality. The neurobiological mechanisms that underlie the functional alterations of WM-FNs in poor sleepers need to be investigated in future studies.