单磷酸己糖(HMP)分流器在维持碳稳态方面是细胞代谢的重要组成部分。HMP分流器包括两个相,即。氧化和非氧化,为合成生物分子如核苷酸提供不同的中间体,DNA,RNA,氨基酸,等等;在氧化应激过程中减少分子合成代谢和解毒活性氧。HMP分流在肝脏中非常重要,脂肪组织,红细胞,肾上腺,泌乳乳腺和睾丸。我们研究了与HMP通路相关的文章,其代谢产物和与代谢异常有关的疾病。本文的文献通常来自个人数据库,Cochrane系统评价数据库,PubMed出版物,生物化学教科书,和电子期刊截止日期在单磷酸己糖分流器上。HMP分流是一个严格控制的代谢途径,它也与体内其他代谢途径如糖酵解相连,糖异生,和葡萄糖醛酸取决于身体的代谢需求和生化需求。HMP分流在NADPH2形成和作为核酸和氨基酸的生物合成前体的戊糖中发挥重要作用。NADPH2可以保护细胞免受高活性氧的影响。单磷酸己糖途径的缺乏与许多疾病有关。此外,据报道,这种代谢途径可以作为治疗不同类型癌症的治疗靶点,因此,在分子水平上的治疗可以通过限制由HMP分流提供的增殖细胞所需的生物分子的合成来计划,因此,还可以进行更多的实验来发现更多的发现。
The hexose monophosphate (
HMP) shunt acts as an essential component of cellular metabolism in maintaining carbon homeostasis. The
HMP shunt comprises two phases viz. oxidative and nonoxidative, which provide different intermediates for the synthesis of biomolecules like nucleotides, DNA, RNA, amino acids, and so forth; reducing molecules for anabolism and detoxifying the reactive oxygen species during oxidative stress. The
HMP shunt is significantly important in the liver, adipose tissue, erythrocytes, adrenal glands, lactating mammary glands and testes. We have researched the articles related to the
HMP pathway, its metabolites and disorders related to its metabolic abnormalities. The literature for this paper was taken typically from a personal database, the Cochrane database of systemic reviews, PubMed publications, biochemistry textbooks, and electronic journals uptil date on the hexose monophosphate shunt. The HMP shunt is a tightly controlled metabolic pathway, which is also interconnected with other metabolic pathways in the body like glycolysis, gluconeogenesis, and glucuronic acid depending upon the metabolic needs of the body and depending upon the biochemical demand. The
HMP shunt plays a significant role in NADPH2 formation and in pentose sugars that are biosynthetic precursors of nucleic acids and amino acids. Cells can be protected from highly reactive oxygen species by NADPH 2 . Deficiency in the hexose monophosphate pathway is linked to numerous disorders. Furthermore, it was also reported that this metabolic pathway could act as a therapeutic target to treat different types of cancers, so treatments at the molecular level could be planned by limiting the synthesis of biomolecules required for proliferating cells provided by the HMP shunt, hence, more experiments still could be carried out to find additional discoveries.