目的:系统评价胃肠安丸(,WCA)联合西药(WM)治疗胃肠道疾病。
方法:八个数据库,包括中国国家知识基础设施数据库,万方数据,中国科技期刊数据库,SinoMed,PubMed,WebofScience,科克伦图书馆,和Embase,从开始到2021年9月30日,我们搜索了WCA的随机对照试验(RCT)。我们独立筛选了文献,提取的数据,然后评估偏差风险,有效性,安全,和其他指标所包含的文章。
结果:本研究共纳入33项RCTs,共3368例患者。经过分析,发现WCA联合WM能有效预防和治疗抗生素相关的胃肠道反应,功能性消化不良(FD),肠易激综合征,轮状病毒腹泻(RVD),溃疡性结肠炎(UC);无严重不良反应发生。此外,与对照组相比,实验组症状和一些生化指标明显改善。
结论:WCA联合WM治疗胃肠道疾病的临床疗效优于对照组。无严重不良反应。值得注意的是,在FD的治疗中,RVD,UC,WCA改善临床症状和生化指标表达。然而,由于文献的质量和数量有限,结果需要使用高质量的RCT进一步研究。
To systematically evaluate the efficacy and safety of Weichang\'an pill (, WCA) combined with Western Medicine (WM) for the treatment of gastrointestinal diseases.
Eight databases, including
China National Knowledge Infrastructure Database, Wanfang Data,
China Science and Technology Journal Database, SinoMed, PubMed, Web of Science, Cochrane Library, and Embase, were searched for randomized controlled trials (RCTs) of WCA from inception to 30 September 2021. We independently screened the literature, extracted data, and then evaluated the bias risk, effectiveness, safety, and other indicators of the included articles.
A total of 33 RCTs were included in this study with 3368 patients. After analysis, it was found that WCA combined with WM could effectively prevent and treat antibiotic-associated gastrointestinal reaction, functional dyspepsia (FD), irritable bowel syndrome, rotavirus diarrhea (RVD), and ulcerative colitis (UC); no serious adverse reactions occurred. Moreover, compared with the control group, the experimental group showed significantly improved symptoms and some biochemical parameters.
WCA combined with WM for the treatment of gastrointestinal diseases had better clinical efficacy than the control group, without serious adverse reactions. Notably, in the treatment of FD, RVD, and UC, WCA improved clinical symptoms and biochemical indicator expression. Nevertheless, owing to the restricted quality and quantity of the literature, the results need to be further studied using high-quality RCTs.